Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MITF | O75030 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | UBE2N | P61088 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22729506 | 0.82 | MAPT (0.53) | MAPTRAB9ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL22754972 | 0.76 | MAPT (0.47) | MAPTRAB9ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL29839337 | 0.74 | MAPT (0.50) | MAPTRAB9ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL22729511 | 0.74 | MAPT (0.50) | MAPTRAB9ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL22754851 | 0.70 | RAB9A (0.52) | MAPTRAB9ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL22729508 | 0.68 | MAPT (0.54) | MAPTRAB9ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL13907635 | 0.67 | NPC1 (1.00) | MAPTRAB9ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL1853814 | 0.67 | MAPT (0.67) | MAPTRAB9ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL22754989 | 0.67 | RAB9A (0.53) | MAPTRAB9ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL22755341 | 0.67 | MAPT (0.45) | MAPTRAB9ASMN1; SMN2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3747885-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2020-12-09 | — | — | EP | disclosed |