Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.45 |
| ▸ | RELA | Q04206 | 2/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HAVCR2 | Q8TDQ0 | 4/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22757151 | 0.86 | MAPT (0.47) | MAPTTP53POLBNPC1RAB9A | |
| SCHEMBL19464495 | 0.79 | TGM2 (0.47) | MAPTTP53POLBNPC1RAB9A | |
| SCHEMBL22757162 | 0.78 | MAPT (0.52) | MAPTTP53POLBNPC1RAB9A | |
| SCHEMBL11714556 | 0.76 | NR1H4 (0.64) | MAPTTP53POLBNPC1RAB9A | |
| SCHEMBL16592529 | 0.74 | PTPN1 (0.61) | MAPTTP53POLBNPC1RAB9A | |
| SCHEMBL3074014 | 0.71 | HDAC1 (0.57) | MAPTTP53POLBNPC1RAB9A | |
| SCHEMBL16592484 | 0.70 | SMN1; SMN2 (0.71) | MAPTTP53POLBNPC1RAB9A | |
| SCHEMBL16592740 | 0.70 | RAB9A (0.60) | MAPTTP53POLBNPC1RAB9A | |
| SCHEMBL16592706 | 0.69 | PRMT1 (0.58) | MAPTTP53POLBNR1H4HDAC4 | |
| SCHEMBL16592774 | 0.69 | S1PR1 (0.70) | MAPTTP53POLBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2853532-B1 | 1,2,4-oxadiazole derivatives as allosteric modulators of metabotropic glutamate receptors belonging to group III | INST FARMAKOLOGII POLSKIEJ AKADEMII NAUK (PL) | 2020-12-09 | — | — | EP | disclosed |