Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HINT1 | P49773 | 5/20 | 0.50 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | NT5E | P21589 | 1/20 | 0.48 |
| ▸ | TGM2 | P21980 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 2/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.45 |
| ▸ | PNP | P00491 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | HBB | P68871 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12636320 | 0.88 | STING1 (0.52) | HINT1STING1ADORA3NT5ETGM2 | |
| SCHEMBL3745431 | 0.87 | ADORA3 (0.55) | HINT1STING1ADORA3NT5ETGM2 | |
| SCHEMBL20394592 | 0.87 | ADORA3 (0.55) | HINT1STING1ADORA3NT5ETGM2 | |
| SCHEMBL1052346 | 0.87 | ADORA3 (0.55) | HINT1STING1ADORA3NT5ETGM2 | |
| SCHEMBL8709916 | 0.87 | ADORA3 (0.55) | HINT1STING1ADORA3NT5ETGM2 | |
| SCHEMBL3745425 | 0.87 | ADORA3 (0.55) | HINT1STING1ADORA3NT5ETGM2 | |
| SCHEMBL1052344 | 0.87 | ADORA3 (0.55) | HINT1STING1ADORA3NT5ETGM2 | |
| SCHEMBL12642435 | 0.87 | ADORA3 (0.55) | HINT1STING1ADORA3NT5ETGM2 | |
| SCHEMBL18522092 | 0.85 | ADORA3 (0.53) | HINT1STING1ADORA3NT5ETGM2 | |
| SCHEMBL6036072 | 0.83 | TGM2 (0.57) | STING1NT5ETGM2HPRT1PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020247633-A1 | THIARABINE- AND THIARABINE PRODRUG-BASED TREATMENTS | SOUTHERN RESEARCH INSTITUTE (US) | 2020-12-10 | — | — | WO | disclosed |