Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 1/20 | 0.57 |
| ▸ | POLG | P54098 | 2/20 | 0.56 |
| ▸ | PNP | P00491 | 2/20 | 0.55 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.54 |
| ▸ | KRAS | P01116 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.51 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.51 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.51 |
| ▸ | NT5E | P21589 | 1/20 | 0.51 |
| ▸ | POLA1 | P09884 | 1/20 | 0.49 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.47 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.46 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.46 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6036078 | 1.00 | TGM2 (0.57) | TGM2POLGPNPFUT5KRAS | |
| SCHEMBL16285167 | 0.89 | TGM2 (0.46) | TGM2POLGPNPFUT5KRAS | |
| SCHEMBL6035291 | 0.86 | POLB (0.57) | TGM2POLGPNPFUT5KRAS | |
| SCHEMBL6035282 | 0.86 | POLB (0.57) | TGM2POLGPNPFUT5KRAS | |
| SCHEMBL22758926 | 0.83 | HINT1 (0.50) | TGM2PNPFUT5NT5ESTING1 | |
| SCHEMBL16130074 | 0.81 | P2RX3 (0.64) | P2RY2P2RX3 | |
| SCHEMBL15747215 | 0.81 | KRAS (0.56) | TGM2POLGPNPFUT5KRAS | |
| Gtp SCHEMBL18271799 | 0.81 | TGM2 (0.81) | TGM2FUT5KRASP2RY2P2RY4 | |
| SCHEMBL19691775 | 0.81 | TGM2 (0.81) | TGM2FUT5KRASP2RY2P2RY4 | |
| Gtp SCHEMBL18784960 | 0.81 | TGM2 (0.81) | TGM2FUT5KRASP2RY2P2RY4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250257090-A1 | Ribonucleic Acids With 4'-Thio-Modified Nucleotides and Related Methods | TRANSLATE BIO, INC. (US) | 2025-08-14 | — | — | US | disclosed |
| US-12247046-B2 | Ribonucleic acids with 4′-thio-modified nucleotides and related methods | TRANSLATE BIO, INC. (US) | 2025-03-11 | — | — | US | disclosed |
| US-20230192753-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | RANA THERAPEUTICS, INC. | 2023-06-22 | — | — | US | disclosed |
| US-20230192753-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | RANA THERAPEUTICS, INC. | 2023-06-22 | — | — | US | disclosed |
| US-20230192753-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | RANA THERAPEUTICS, INC. | 2023-06-22 | — | — | US | disclosed |
| US-11447520-B2 | Ribonucleic acids with 4′-thio-modified nucleotides and related methods | TRANSLATE BIO, INC. (US) | 2022-09-20 | — | — | US | disclosed |
| US-20210009629-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | TRANSLATE BIO, INC. | 2021-01-14 | — | — | US | disclosed |
| US-20210009629-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | TRANSLATE BIO, INC. | 2021-01-14 | — | — | US | disclosed |
| EP-3750903-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | Translate Bio, Inc. (US) | 2020-12-16 | — | — | EP | disclosed |
| US-10822368-B2 | Ribonucleic acids with 4′-thio-modified nucleotides and related methods | TRANSLATE BIO, INC. (US) | 2020-11-03 | — | — | US | disclosed |
| EP-2970351-B1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | TRANSLATE BIO INC (US) | 2017-09-13 | — | — | EP | disclosed |
| US-20160031928-A1 | RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | TRANSLATE BIO, INC. | 2016-02-04 | — | — | US | disclosed |
| US-20160031928-A1 | RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | TRANSLATE BIO, INC. | 2016-02-04 | — | — | US | disclosed |
| US-20160031928-A1 | RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | TRANSLATE BIO, INC. | 2016-02-04 | — | — | US | disclosed |
| EP-2970351-A1 | RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | Shire Human Genetic Therapies, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| US-20140364446-A1 | 1',4'-THIO NUCLEOSIDES FOR THE TREATMENT OF HCV | UNIVERSITE DE MONTPELLIER (FR) | 2014-12-11 | — | — | US | disclosed |
| WO-2014152513-A1 | RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2014152513-A1 | RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2014-09-25 | — | — | WO | disclosed |
| US-20060127990-A1 | 4'-thionucleotide | GENETICLAB CO., LTD (JP) | 2006-06-15 | — | — | US | disclosed |
| EP-1541581-A1 | 4 -THIONUCLEOTIDE | Geneticlab Co., Ltd. (JP) | 2005-06-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250257090-A1 | Ribonucleic Acids With 4'-Thio-Modified Nucleotides and Related Methods | RNMT, RNGTT, NSUN3 | TGM2 1205/4885POLG 1468/4885PNP 95/4885 |
| US-10822368-B2 | Ribonucleic acids with 4′-thio-modified nucleotides and related methods | RNMT, RNGTT, NSUN3 | TGM2 1219/4885POLG 1457/4885PNP 95/4885 |
| US-20210009629-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | RNMT, RNGTT, NSUN3 | TGM2 1205/4885POLG 1468/4885PNP 95/4885 |
| US-12247046-B2 | Ribonucleic acids with 4′-thio-modified nucleotides and related methods | RNMT, RNGTT, NSUN3 | TGM2 1219/4885POLG 1457/4885PNP 95/4885 |
| US-20230192753-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | RNMT, RNGTT, NSUN3 | TGM2 1205/4885POLG 1468/4885PNP 95/4885 |
| US-20060127990-A1 | 4'-thionucleotide | NT5C3B, RNGTT, TYMP | TGM2 865/4885POLG 220/4885PNP 18/4885 |
| US-20140364446-A1 | 1',4'-THIO NUCLEOSIDES FOR THE TREATMENT OF HCV | SLC29A1, SLC28A1, TPMT | TGM2 1427/4885POLG 1162/4885PNP 6/4885 |
| US-20160031928-A1 | RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | RNMT, RNGTT, NSUN3 | TGM2 1205/4885POLG 1468/4885PNP 95/4885 |
| US-11447520-B2 | Ribonucleic acids with 4′-thio-modified nucleotides and related methods | RNMT, RNGTT, NSUN3 | TGM2 1219/4885POLG 1457/4885PNP 95/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.