Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MAT2A | P31153 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22760085 | 0.89 | EDNRA (0.37) | MAT2ALMNAALDH1A1GAATP53 | |
| SCHEMBL22760158 | 0.84 | NOTUM (0.41) | NOTUMHPGDLMNANPSR1MEN1 | |
| SCHEMBL22748242 | 0.82 | NOTUM (0.38) | NOTUMHPGDMAT2ALMNANPSR1 | |
| SCHEMBL22747882 | 0.81 | HTT (0.37) | NOTUMHPGDTDP1MEN1KMT2A | |
| SCHEMBL22760095 | 0.80 | MAPT (0.48) | HPGDMAT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL22760117 | 0.80 | FOLH1 (0.36) | LMNAKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL22760364 | 0.79 | FOLH1 (0.37) | NOTUMMAT2ALMNAALDH1A1KMT2A | |
| SCHEMBL22747829 | 0.78 | FOLH1 (0.35) | NOTUMLMNAALDH1A1GAATP53 | |
| SCHEMBL22748255 | 0.78 | NOTUM (0.41) | NOTUMHPGDKDM4EMEN1ALDH1A1 | |
| SCHEMBL22760062 | 0.77 | EDNRA (0.39) | MAT2ALMNAMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |