Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | MAT2A | P31153 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22747852 | 0.92 | EDNRA (0.40) | EDNRAMAPK8MAPK9MAPK10FOLH1 | |
| SCHEMBL22760511 | 0.86 | MAPK8 (0.38) | EDNRAMAPK8MAPK9MAPK10MALT1 | |
| SCHEMBL22760385 | 0.80 | MAPK8 (0.49) | MAPK8 | |
| SCHEMBL22760423 | 0.78 | MAPT (0.46) | MAPK8MAPK9MAPK10MAT2A | |
| SCHEMBL22747848 | 0.71 | MAT2A (0.44) | EDNRAMAPK8MAT2A | |
| SCHEMBL22760439 | 0.71 | HPGD (0.47) | EDNRAMAPK8MAPK9MAT2A | |
| SCHEMBL22747870 | 0.70 | FOLH1 (0.42) | EDNRAMAPK8MAPK9FOLH1MAT2A | |
| SCHEMBL22747899 | 0.69 | HTR1A (0.40) | RENEDNRAHTR1ASLC6A2SLC6A4 | |
| SCHEMBL27302554 | 0.68 | MAPK8 (0.41) | MAPK8MAPK9MAT2A | |
| SCHEMBL22747914 | 0.66 | MAPK8 (0.40) | EDNRAMAPK8MAPK9FOLH1MAT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |