Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 9/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22760499 | 0.94 | NOTUM (0.37) | SMN1; SMN2HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL22760063 | 0.92 | EDNRA (0.39) | HPGDALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL22747830 | 0.92 | EDNRA (0.39) | HPGDALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL22760112 | 0.92 | NOTUM (0.37) | SMN1; SMN2HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL22760500 | 0.92 | HPGD (0.35) | SMN1; SMN2HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL22748355 | 0.91 | EDNRA (0.40) | SMN1; SMN2HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL22748438 | 0.90 | SMN1; SMN2 (0.43) | SMN1; SMN2HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL22760126 | 0.90 | EDNRA (0.41) | SMN1; SMN2HPGDALDH1A1EDNRARAB9A | |
| SCHEMBL22760177 | 0.89 | AKR1C3 (0.44) | SMN1; SMN2HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL22760215 | 0.85 | HPGD (0.51) | SMN1; SMN2HPGDALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| CN-112028815-A | Indole derivatives and medical application thereof | 中国药科大学 | 2020-12-04 | — | — | CN | disclosed |