Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 6/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22760063 | 0.99 | EDNRA (0.39) | EDNRAHPGDHSD17B10ALDH1A1GAA | |
| SCHEMBL22747830 | 0.99 | EDNRA (0.39) | EDNRAHPGDHSD17B10ALDH1A1GAA | |
| SCHEMBL22760100 | 0.91 | SMN1; SMN2 (0.40) | EDNRAHPGDHSD17B10ALDH1A1GAA | |
| SCHEMBL22747879 | 0.90 | HPGD (0.42) | EDNRAHPGDALDH1A1GAAMEN1 | |
| SCHEMBL22760076 | 0.90 | EDNRA (0.38) | EDNRAHPGDHSD17B10ALDH1A1LMNA | |
| SCHEMBL22760496 | 0.90 | REN (0.40) | EDNRAHPGDHSD17B10ALDH1A1KDM4E | |
| SCHEMBL22760499 | 0.89 | NOTUM (0.37) | EDNRAHPGDHSD17B10ALDH1A1GAA | |
| SCHEMBL22760091 | 0.89 | KDM4E (0.38) | EDNRAALDH1A1KDM4ELMNAMALT1 | |
| SCHEMBL22760495 | 0.88 | FOLH1 (0.37) | EDNRAHPGDHSD17B10ALDH1A1GAA | |
| SCHEMBL22760118 | 0.87 | GAA (0.38) | EDNRAHPGDHSD17B10ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| CN-112028815-A | Indole derivatives and medical application thereof | 中国药科大学 | 2020-12-04 | — | — | CN | disclosed |