Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22760385 | 0.90 | MAPK8 (0.49) | MAPK8TP53POLBMEN1KMT2A | |
| SCHEMBL22760423 | 0.88 | MAPT (0.46) | MAPK8TP53ALDH1A1MEN1KMT2A | |
| SCHEMBL22748436 | 0.77 | MAPK8 (0.46) | MAPK8TP53POLBALDH1A1MEN1 | |
| SCHEMBL22760511 | 0.75 | MAPK8 (0.38) | MAPK8ALDH1A1 | |
| SCHEMBL22760129 | 0.75 | ALDH1A1 (0.50) | MAPK8TP53ALDH1A1MEN1KMT2A | |
| SCHEMBL22760422 | 0.75 | ALDH1A1 (0.50) | MAPK8TP53POLBALDH1A1MEN1 | |
| SCHEMBL22747852 | 0.74 | EDNRA (0.40) | MAPK8 | |
| SCHEMBL2567265 | 0.74 | CCR3 (0.56) | MAPK8TP53ALDH1A1MEN1KMT2A | |
| SCHEMBL22748277 | 0.73 | MEN1 (0.46) | MAPK8TP53ALDH1A1MEN1KMT2A | |
| SCHEMBL22760130 | 0.73 | ALDH1A1 (0.47) | MAPK8TP53POLBALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |