Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22760191 | 0.90 | MAPK8 (0.46) | MAPK8TP53NPBWR1MCHR1GPR119 | |
| SCHEMBL22747874 | 0.86 | MAPT (0.43) | TP53ALDH1A1GAAMEN1KMT2A | |
| SCHEMBL22760197 | 0.79 | MAPT (0.42) | MAPK8TP53ALDH1A1GAAMEN1 | |
| SCHEMBL22760106 | 0.77 | MAPK8 (0.49) | MAPK8TP53POLBGPR119LMNA | |
| SCHEMBL22760097 | 0.75 | CHRM4 (0.45) | MCHR1ALDH1A1MEN1KMT2A | |
| SCHEMBL22760562 | 0.71 | ALDH1A1 (0.67) | MAPK8TP53POLBALOX15LMNA | |
| SCHEMBL22760558 | 0.69 | ALDH1A1 (0.52) | MAPK8TP53POLBALOX15LMNA | |
| SCHEMBL1769219 | 0.69 | USP30 (0.71) | GPR119MEN1KMT2AUSP30PIK3CD | |
| SCHEMBL21409063 | 0.69 | USP30 (0.71) | GPR119MEN1KMT2AUSP30PIK3CD | |
| SCHEMBL5153452 | 0.69 | USP30 (0.71) | GPR119MEN1KMT2AUSP30PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |