Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22760215 | 0.92 | HPGD (0.51) | MAPTALDH1A1GAAHPGDTHRB | |
| SCHEMBL22747825 | 0.91 | HPGD (0.45) | MAPTALDH1A1GAAHPGDTHRB | |
| SCHEMBL22760342 | 0.91 | HPGD (0.45) | MAPTALDH1A1GAAHPGDTHRB | |
| SCHEMBL22747823 | 0.90 | ALDH1A1 (0.45) | MAPTALDH1A1GAAHPGDTHRB | |
| SCHEMBL22760172 | 0.90 | MAPT (0.47) | MAPTALDH1A1GAAHPGDTHRB | |
| SCHEMBL22760232 | 0.89 | HPGD (0.44) | MAPTALDH1A1HPGDTHRBTP53 | |
| SCHEMBL22747861 | 0.89 | MAPK8 (0.41) | — | |
| SCHEMBL22760359 | 0.88 | ALDH1A1 (0.46) | MAPTALDH1A1GAAHPGDTHRB | |
| SCHEMBL22760157 | 0.87 | TSHR (0.43) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL22760063 | 0.85 | EDNRA (0.39) | MAPTALDH1A1GAAHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |