Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.69 |
| ▸ | NPC1 | O15118 | 6/20 | 0.69 |
| ▸ | RAB9A | P51151 | 6/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | ATM | Q13315 | 1/20 | 0.69 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
| ▸ | CCR5 | P51681 | 1/20 | 0.45 |
| ▸ | CCR8 | P51685 | 1/20 | 0.45 |
| ▸ | METAP1 | P53582 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1424929 | 0.82 | KDM4E (1.00) | KDM4ENPC1RAB9AMAPTATM | |
| SCHEMBL3715917 | 0.79 | NPC1 (0.65) | KDM4ENPC1RAB9AMAPTATM | |
| SCHEMBL8143194 | 0.78 | KDM4E (0.74) | KDM4ENPC1RAB9AMAPTATM | |
| SCHEMBL15671504 | 0.76 | KDM4E (0.77) | KDM4ENPC1RAB9AMAPTATM | |
| SCHEMBL29870798 | 0.76 | KDM4E (0.77) | KDM4ENPC1RAB9AMAPTATM | |
| SCHEMBL17135790 | 0.74 | KDM4E (0.74) | KDM4ENPC1RAB9AMAPTATM | |
| SCHEMBL971007 | 0.74 | KDM4E (0.74) | KDM4ENPC1RAB9AMAPTATM | |
| SCHEMBL11982530 | 0.74 | KDM4E (0.74) | KDM4ENPC1RAB9AMAPTATM | |
| SCHEMBL3334264 | 0.73 | CA1 (0.61) | KDM4ENPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL1208215 | 0.72 | KDM4E (0.70) | KDM4ENPC1RAB9AMAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020247819-A2 | METHODS OF TREATMENT WITH AMINOLEVULINIC ACID SYNTHASE 2 (ALAS2) MODULATORS | AGIOS PHARMACEUTICALS, INC. (US) | 2020-12-10 | — | — | WO | disclosed |