Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.74 |
| ▸ | RAB9A | P51151 | 7/20 | 0.74 |
| ▸ | NPC1 | O15118 | 6/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.74 |
| ▸ | ATM | Q13315 | 1/20 | 0.74 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.49 |
| ▸ | TP53 | P04637 | 5/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | CCR1 | P32246 | 2/20 | 0.48 |
| ▸ | CCR5 | P51681 | 2/20 | 0.48 |
| ▸ | CCR8 | P51685 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | METAP1 | P53582 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1424929 | 0.86 | KDM4E (1.00) | KDM4ERAB9ANPC1MAPTATM | |
| SCHEMBL15671504 | 0.78 | KDM4E (0.77) | KDM4ERAB9ANPC1MAPTATM | |
| SCHEMBL29870798 | 0.78 | KDM4E (0.77) | KDM4ERAB9ANPC1MAPTATM | |
| SCHEMBL17135790 | 0.77 | KDM4E (0.74) | KDM4ERAB9ANPC1MAPTATM | |
| SCHEMBL8143194 | 0.77 | KDM4E (0.74) | KDM4ERAB9ANPC1MAPTATM | |
| SCHEMBL11982530 | 0.77 | KDM4E (0.74) | KDM4ERAB9ANPC1MAPTATM | |
| SCHEMBL8032949 | 0.76 | KDM4E (0.41) | KDM4ERAB9ANPC1MAPTATM | |
| SCHEMBL10365075 | 0.75 | TERT (0.39) | KDM4ERAB9ANPC1MAPTATM | |
| SCHEMBL22761302 | 0.74 | KDM4E (0.69) | KDM4ERAB9ANPC1MAPTATM | |
| SCHEMBL971837 | 0.73 | KDM4E (0.49) | KDM4ERAB9ANPC1MAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0285565-B1 | 2-MERCAPTO-5-PYRIDYL-1,3,4-OXADIAZOLES AND 1,3,4-THIADIAZOLES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS NEMATICIDAL AGENTS | CIBA-GEIGY AG (CH) | 1993-09-15 | — | — | EP | claimed |
| US-4894380-A | NEMATOCIDES | CIBA-GEIGY CORPORATION (US) | 1990-01-16 | — | — | US | claimed |
| EP-0285565-A2 | 2-Mercapto-5-pyridyl-1,3,4-oxadiazoles and 1,3,4-thiadiazoles, process for their preparation and their use as nematicidal agents | CIBA-GEIGY AG (CH) | 1988-10-05 | — | — | EP | claimed |
| US-20230321091-A1 | SUBSTITUTED PYRIDAZINONES FOR USE IN THE TREATMENT OF NEUROMUSCULAR DISEASES | EDGEWISE THERAPEUTICS, INC. | 2023-10-12 | — | — | US | disclosed |
| US-7871982-B2 | Lincomycin derivatives and antimicrobial agents comprising the same as active ingredient | MEIJI SEIKA KAISHA, LTD. (JP) | 2011-01-18 | — | — | US | disclosed |
| US-20090156512-A1 | potent activity against resistant pneumococci | MEIJI SEIKA KAISHA, LTD. (JP) | 2009-06-18 | — | — | US | disclosed |
| EP-1970377-A1 | LINCOMYCIN DERIVATIVE AND ANTIBACTERIAL AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT | MEIJI SEIKA KAISHA LTD. (JP) | 2008-09-17 | — | — | EP | disclosed |
| US-20070184383-A1 | Photosensitive composition, photosensitive planographic printing plate material, and recording method of planographic printing plate material | KONICA MINOLTA MEDICAL & GRAPHIC, INC. | 2007-08-09 | — | — | US | disclosed |
| US-20070184383-A1 | Photosensitive composition, photosensitive planographic printing plate material, and recording method of planographic printing plate material | KONICA MINOLTA MEDICAL & GRAPHIC, INC. | 2007-08-09 | — | — | US | disclosed |
| CN-1948307-A | Preparation method of 5-(2-pyridyl)-2-sulfhydryl-1,3,4-thiadiazole | SICHUAN BEILIKE BIOTECH CO LTD (CN) | 2007-04-18 | — | — | CN | disclosed |
| CN-1948307-A | Preparation method of 5-(2-pyridyl)-2-sulfhydryl-1,3,4-thiadiazole | SICHUAN BEILIKE BIOTECH CO LTD (CN) | 2007-04-18 | — | — | CN | disclosed |
| US-5248782-A | Fluorescent dyes | MOLECULAR PROBES, INC. (US) | 1993-09-28 | — | — | US | disclosed |
| EP-0285565-B1 | 2-MERCAPTO-5-PYRIDYL-1,3,4-OXADIAZOLES AND 1,3,4-THIADIAZOLES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS NEMATICIDAL AGENTS | CIBA-GEIGY AG (CH) | 1993-09-15 | — | — | EP | disclosed |
| US-4894380-A | NEMATOCIDES | CIBA-GEIGY CORPORATION (US) | 1990-01-16 | — | — | US | disclosed |
| US-4894380-A | NEMATOCIDES | CIBA-GEIGY CORPORATION (US) | 1990-01-16 | — | — | US | disclosed |
| US-4894380-A | NEMATOCIDES | CIBA-GEIGY CORPORATION (US) | 1990-01-16 | — | — | US | disclosed |
| US-4861367-A | 2-Mercapto-5-pyrazinyl-1,3,4-oxadiazoles or 2-mercapto-5-pyrazinyl-1,3,4-thiadiazoles as nematicides | CIBA-GEIGY CORPORATION (US) | 1989-08-29 | — | — | US | disclosed |
| EP-0290379-A2 | 2-Mercapto-5-pyrazinyl-1,3,4-oxadiazoles and -1,3,4-thiadiazoles, process for their preparation and their use as nematicidal agents | CIBA-GEIGY AG (CH) | 1988-11-09 | — | — | EP | disclosed |
| EP-0285565-A2 | 2-Mercapto-5-pyridyl-1,3,4-oxadiazoles and 1,3,4-thiadiazoles, process for their preparation and their use as nematicidal agents | CIBA-GEIGY AG (CH) | 1988-10-05 | — | — | EP | disclosed |
| EP-0285565-A2 | 2-Mercapto-5-pyridyl-1,3,4-oxadiazoles and 1,3,4-thiadiazoles, process for their preparation and their use as nematicidal agents | CIBA-GEIGY AG (CH) | 1988-10-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230321091-A1 | SUBSTITUTED PYRIDAZINONES FOR USE IN THE TREATMENT OF NEUROMUSCULAR DISEASES | IL6, MUSK, SMN1; SMN2 | KDM4E 3081/4885RAB9A 2744/4885NPC1 4135/4885 |
| US-20090156512-A1 | potent activity against resistant pneumococci | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, NAT1, NPM1 | KDM4E 3077/4885RAB9A 377/4885NPC1 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.