Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.74 |
| ▸ | NPC1 | O15118 | 6/20 | 0.74 |
| ▸ | RAB9A | P51151 | 5/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.74 |
| ▸ | ATM | Q13315 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.49 |
| ▸ | TP53 | P04637 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CCR1 | P32246 | 1/20 | 0.48 |
| ▸ | CCR5 | P51681 | 1/20 | 0.48 |
| ▸ | CCR8 | P51685 | 1/20 | 0.48 |
| ▸ | METAP1 | P53582 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1424929 | 0.86 | KDM4E (1.00) | KDM4ENPC1RAB9AMAPTATM | |
| SCHEMBL3137543 | 0.84 | KDM4E (0.53) | KDM4ENPC1RAB9AMAPTATM | |
| SCHEMBL1208215 | 0.79 | KDM4E (0.70) | KDM4ENPC1RAB9AMAPTATM | |
| SCHEMBL29870798 | 0.78 | KDM4E (0.77) | KDM4ENPC1RAB9AMAPTATM | |
| SCHEMBL15671504 | 0.78 | KDM4E (0.77) | KDM4ENPC1RAB9AMAPTATM | |
| SCHEMBL22761302 | 0.78 | KDM4E (0.69) | KDM4ENPC1RAB9AMAPTATM | |
| SCHEMBL11982530 | 0.77 | KDM4E (0.74) | KDM4ENPC1RAB9AMAPTATM | |
| SCHEMBL971007 | 0.77 | KDM4E (0.74) | KDM4ENPC1RAB9AMAPTATM | |
| SCHEMBL17135790 | 0.77 | KDM4E (0.74) | KDM4ENPC1RAB9AMAPTATM | |
| SCHEMBL17835736 | 0.76 | KDM4E (0.56) | KDM4ENPC1RAB9AMAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119751439-A | ATF6 modulators and uses thereof | 阿尔托斯实验室公司 | 2025-04-04 | — | — | CN | disclosed |
| CN-115087656-B | ATF6 modulators and uses thereof | 阿尔托斯实验室公司 | 2024-12-13 | — | — | CN | disclosed |
| US-20240270735-A1 | CDK19-Selective Inhibitors, and Methods of Use Thereof | CHAN ZUCKERBERG BIOHUB, INC. | 2024-08-15 | — | — | US | disclosed |
| CN-112279845-B | Aryl or heteroaryl substituted thiadiazoles compounds and antibacterial application thereof | 中国医学科学院药物研究所 | 2023-07-28 | — | — | CN | disclosed |
| US-20230028584-A1 | ATF6 MODULATORS AND USES THEREOF | ALTOS LABS, INC. | 2023-01-26 | — | — | US | disclosed |
| US-20230028584-A1 | ATF6 MODULATORS AND USES THEREOF | ALTOS LABS, INC. | 2023-01-26 | — | — | US | disclosed |
| CN-115087656-A | ATF6 modulators and uses thereof | 普拉西斯生物技术有限责任公司 | 2022-09-20 | — | — | CN | disclosed |
| EP-4041728-A1 | ATF6 MODULATORS AND USES THEREOF | Praxis Biotech LLC (US) | 2022-08-17 | — | — | EP | disclosed |
| WO-2021069721-A1 | ATF6 MODULATORS AND USES THEREOF | BLACK BELT TX LTD (GB) | 2021-04-15 | — | — | WO | disclosed |
| WO-2021069721-A1 | ATF6 MODULATORS AND USES THEREOF | BLACK BELT TX LTD (GB) | 2021-04-15 | — | — | WO | disclosed |
| CN-112279845-A | Aryl or heteroaryl substituted thiadiazole compounds and antibacterial application thereof | 中国医学科学院药物研究所 | 2021-01-29 | — | — | CN | disclosed |
| US-20170107212-A1 | NOVEL COMPOUNDS | Bayer Pharma AG (DE) | 2017-04-20 | — | — | US | disclosed |
| EP-3119759-A1 | NOVEL COMPOUNDS | Bayer Pharma Aktiengesellschaft (DE) | 2017-01-25 | — | — | EP | disclosed |
| WO-2015140195-A1 | NOVEL COMPOUNDS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-09-24 | — | — | WO | disclosed |
| CN-104098609-A | Imidazole and [2,1-b]-1,3,4-thiadiazole containing ferrocene, preparation method and application thereof | UNIV SHAANXI SCIENCE & TECH | 2014-10-15 | — | — | CN | disclosed |
| EP-1054876-A1 | 1,3,4-THIADIAZOLES DERIVATIVES AS KYN-OH INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999028309-A1 | 1,3,4-THIADIAZOLES DERIVATIVES AS KYN-OH INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240270735-A1 | CDK19-Selective Inhibitors, and Methods of Use Thereof | CDK19, CDK9, CDK1 | KDM4E 904/4885NPC1 3644/4885RAB9A 651/4885 |
| US-20170107212-A1 | NOVEL COMPOUNDS | WNT1, CTNNB1, WNT3A | KDM4E 3482/4885NPC1 356/4885RAB9A 1164/4885 |
| US-20230028584-A1 | ATF6 MODULATORS AND USES THEREOF | ATF4, XBP1, ATF1 | KDM4E 4378/4885NPC1 179/4885RAB9A 2353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.