Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A1 | O15245 | 1/20 | 0.67 |
| ▸ | HTR1A | P08908 | 1/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.67 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.67 |
| ▸ | MAOA | P21397 | 1/20 | 0.67 |
| ▸ | DRD1 | P21728 | 1/20 | 0.67 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.67 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.67 |
| ▸ | HTR2A | P28223 | 1/20 | 0.67 |
| ▸ | HTR2C | P28335 | 1/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.67 |
| ▸ | DRD3 | P35462 | 1/20 | 0.67 |
| ▸ | HTR2B | P41595 | 1/20 | 0.67 |
| ▸ | MTOR | P42345 | 1/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17704923 | 0.81 | SLC22A1 (0.73) | SLC22A1HTR1AADRA2ACHRM1ADRA2B | |
| Guanabenz SCHEMBL219392 | 0.80 | TAAR1 (1.00) | SLC22A1HTR1AADRA2ACHRM1ADRA2B | |
| Guanabenz SCHEMBL15390 | 0.80 | TAAR1 (1.00) | SLC22A1HTR1AADRA2ACHRM1ADRA2B | |
| Guanabenz SCHEMBL3054917 | 0.75 | NPSR1 (1.00) | SLC22A1HTR1AADRA2ACHRM1ADRA2B | |
| SCHEMBL6332335 | 0.75 | GRIN2D (0.66) | NPSR1CYP1A2LMNAMAPTRAB9A | |
| Guanoxabenz SCHEMBL17802522 | 0.75 | SLC22A1 (0.69) | SLC22A1HTR1AADRA2ACHRM1ADRA2B | |
| Guanoxabenz SCHEMBL122727 | 0.75 | SLC22A1 (0.69) | SLC22A1HTR1AADRA2ACHRM1ADRA2B | |
| SCHEMBL18155137 | 0.75 | GRIN2D (0.66) | NPSR1CYP1A2LMNAMAPTRAB9A | |
| Guanoxabenz SCHEMBL19715284 | 0.75 | SLC22A1 (0.69) | SLC22A1HTR1AADRA2ACHRM1ADRA2B | |
| SCHEMBL8925019 | 0.73 | SLC22A1 (0.67) | SLC22A1HTR1AADRA2ACHRM1ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020247819-A2 | METHODS OF TREATMENT WITH AMINOLEVULINIC ACID SYNTHASE 2 (ALAS2) MODULATORS | AGIOS PHARMACEUTICALS, INC. (US) | 2020-12-10 | — | — | WO | disclosed |