Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Guanabenz. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 1.00 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 1.00 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 1.00 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
| ▸ | MAOA | P21397 | 1/20 | 1.00 |
| ▸ | DRD1 | P21728 | 1/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | HTR2C | P28335 | 1/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 1/20 | 1.00 |
| ▸ | DRD3 | P35462 | 1/20 | 1.00 |
| ▸ | HTR2B | P41595 | 1/20 | 1.00 |
| ▸ | MTOR | P42345 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanabenz SCHEMBL219392 | 1.00 | TAAR1 (1.00) | TAAR1SLC22A1HTR1AADRA2ACHRM1 | |
| Guanabenz SCHEMBL3054917 | 0.90 | NPSR1 (1.00) | TAAR1SLC22A1HTR1AADRA2ACHRM1 | |
| SCHEMBL17704923 | 0.85 | SLC22A1 (0.73) | TAAR1SLC22A1HTR1AADRA2ACHRM1 | |
| Guanoxabenz SCHEMBL19715284 | 0.82 | SLC22A1 (0.69) | TAAR1SLC22A1HTR1AADRA2ACHRM1 | |
| Guanoxabenz SCHEMBL122727 | 0.82 | SLC22A1 (0.69) | TAAR1SLC22A1HTR1AADRA2ACHRM1 | |
| Guanoxabenz SCHEMBL17802522 | 0.82 | SLC22A1 (0.69) | TAAR1SLC22A1HTR1AADRA2ACHRM1 | |
| SCHEMBL8925019 | 0.80 | SLC22A1 (0.67) | TAAR1SLC22A1HTR1AADRA2ACHRM1 | |
| SCHEMBL8925014 | 0.80 | SLC22A1 (0.67) | TAAR1SLC22A1HTR1AADRA2ACHRM1 | |
| SCHEMBL22761365 | 0.80 | SLC22A1 (0.67) | TAAR1SLC22A1HTR1AADRA2ACHRM1 | |
| SCHEMBL30872248 | 0.79 | NPSR1 (1.00) | TAAR1SLC22A1HTR1AADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 10005 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4724049-A1 | MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF | Catalent Ontario Limited (CA) | 2026-04-15 | — | — | EP | claimed |
| EP-4709883-A2 | MICRORNA AS A DIAGNOSTIC TOOL AND FOR DEVELOPING ADVANCED THERAPIES OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) WITH BULBAR ONSET | Fondazione IRCCS Istituto Neurologico Carlo Besta (IT) | 2026-03-18 | — | — | EP | claimed |
| EP-4704826-A1 | COMPOSITIONS AND METHODS FOR TREATING POST-TRAUMATIC STRESS DISORDER | Yale University (US) | 2026-03-11 | — | — | EP | claimed |
| EP-4704839-A2 | IMIDAZOLE CONTAINING COMPOUNDS, DERIVATIVES THEREFORE, AND USES THEREOF | ALPHERABIO LLC (US) | 2026-03-11 | — | — | EP | claimed |
| US-20250387425-A1 | NOVEL PERSONAL NEOANTIGEN VACCINES AND MARKERS | ANDA BIOLOGY MEDICINE DEV SHENZHEN CO LTD (CN) | 2025-12-25 | — | — | US | claimed |
| US-12472158-B2 | Methods of treating trigeminal nerve pain | VANDERBILT UNIVERSITY (US) | 2025-11-18 | — | — | US | claimed |
| US-20250268847-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF DEMYELINATING DISORDERS | THE UNIVERSITY OF CHICAGO (US) | 2025-08-28 | — | — | US | claimed |
| US-12350379-B2 | Extended release pharmaceutical formulation and methods of treatment | DOUGLAS PHARMACETICALS LTD (NZ) | 2025-07-08 | — | — | US | claimed |
| US-20250213647-A1 | CHEMOKINE RECEPTORS AND ALPHA1 ADRENERGIC RECEPTORS/VASOPRESSIN RECEPTORS 1A HETEROMERS AS DRUG TARGETS FOR DISEASE | UNIVERSITY OF SOUTH FLORIDA | 2025-07-03 | — | — | US | claimed |
| WO-2025131019-A1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF INHIBIN SUBUNIT BETA E (INHBE) | SHANGHAI ARGO BIOPHARMACEUTICAL CO., LTD. (CN) | 2025-06-26 | — | — | WO | claimed |
| US-4783456-A | A-ADRENERGIC BLOCKING AGENTS | RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC. (US) | 1988-11-08 | — | — | US | claimed |
| EP-0268912-A2 | Pharmaceutical composition comprising alpha-2I-selective adrenergic receptor agonists and the use thereof in memory enhancement | YALE UNIVERSITY (US) | 1988-06-01 | — | — | EP | claimed |
| EP-0256798-A1 | Anaesthetic composition | Anaquest, Inc. (US) | 1988-02-24 | — | — | EP | claimed |
| EP-0165696-A2 | Improved transdermal dosage form | AMERICAN HOME PRODUCTS CORPORATION (US) | 1985-12-27 | — | — | EP | claimed |
| US-4559222-A | MINERAL OIL POLYISOBUTYLENE, COLLOIDAL SILICON DIOXIDE MIXTURE; CONTROLLED RELEASE | ALZA CORPORATION (US) | 1985-12-17 | — | — | US | claimed |
| US-4557934-A | ALONG WITH A DIOL PYRROLIDONE OR AN AZACYCLOPENTAN-2-ONE | THE PROCTER & GAMBLE COMPANY (US) | 1985-12-10 | — | — | US | claimed |
| EP-0156592-A2 | Substained release pharmaceutical capsules | AMERICAN HOME PRODUCTS CORPORATION (US) | 1985-10-02 | — | — | EP | claimed |
| WO-1985004100-A1 | SUSTAINED RELEASE PHARMACEUTICAL CAPSULES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1985-09-26 | — | — | WO | claimed |
| EP-0131698-A2 | Guanabenz pharmaceutical composition | BEECHAM GROUP PLC (GB) | 1985-01-23 | — | — | EP | claimed |
| US-4312886-A | (286-DICHLOROBENZYLIDENE)AMINO-GUANIDINE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-01-26 | — | — | US | claimed |