Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Guanabenz. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.81 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.81 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.81 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.81 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.81 |
| ▸ | HTR1A | P08908 | 1/20 | 0.81 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.81 |
| ▸ | MAOA | P21397 | 1/20 | 0.81 |
| ▸ | DRD1 | P21728 | 1/20 | 0.81 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.81 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.81 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanabenz SCHEMBL15390 | 0.90 | TAAR1 (1.00) | NPSR1LMNACYP1A2CYP2D6TSHR | |
| Guanabenz SCHEMBL219392 | 0.90 | TAAR1 (1.00) | NPSR1LMNACYP1A2CYP2D6TSHR | |
| Acetic Acid SCHEMBL29736263 | 0.83 | NPSR1 (0.82) | NPSR1LMNACYP1A2CYP2D6TSHR | |
| SCHEMBL17704923 | 0.83 | SLC22A1 (0.73) | NPSR1LMNACYP1A2CYP2D6TSHR | |
| SCHEMBL11754270 | 0.78 | NPSR1 (0.63) | NPSR1LMNACYP1A2CYP2D6TSHR | |
| SCHEMBL22761365 | 0.75 | SLC22A1 (0.67) | NPSR1LMNACYP1A2CYP2D6TSHR | |
| Guanabenz SCHEMBL9580574 | 0.74 | CYP1A2 (0.58) | NPSR1LMNACYP1A2CYP2D6TSHR | |
| Guanabenz SCHEMBL21519525 | 0.74 | CYP1A2 (0.58) | NPSR1LMNACYP1A2CYP2D6TSHR | |
| Guanabenz SCHEMBL40594 | 0.74 | CYP1A2 (0.58) | NPSR1LMNACYP1A2CYP2D6TSHR | |
| Guanabenz SCHEMBL11756795 | 0.74 | CYP1A2 (0.58) | NPSR1LMNACYP1A2CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120018740-A | Flexible perovskite thin film, preparation method thereof and flexible perovskite solar cell | 景德镇陶瓷大学 | 2025-05-16 | — | — | CN | disclosed |
| US-20230192786-A1 | STAT3 INHIBITION FOR TREATMENT AND PREVENTION OF HUMAN CORONAVIRUS INFECTION | GLG PHARMA LLC (US) | 2023-06-22 | — | — | US | disclosed |
| US-11242555-B2 | Molecular sensors and uses thereof | NEW YORK UNIVERSITY (US) | 2022-02-08 | — | — | US | disclosed |
| US-20200095627-A1 | MOLECULAR SENSORS AND USES THEREOF | NEW YORK UNIVERSITY | 2020-03-26 | — | — | US | disclosed |
| CN-101896161-A | Solid formulations of crystalline compounds | PURDUE RESEARCH FOUNDATION | 2010-11-24 | — | — | CN | disclosed |
| US-20100222311-A1 | SOLID FORMULATIONS OF CRYSTALLINE COMPOUNDS | PURDUE RESEARCH FOUNDATION (US) | 2010-09-02 | — | — | US | disclosed |