Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.41 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | PDE8B | O95263 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22768008 | 0.85 | DAGLA (0.45) | DAGLAHRH3BTKKCNJ6KCNJ5 | |
| SCHEMBL30745364 | 0.80 | PDE8B (0.46) | MEN1KMT2ATSHRALDH1A1LMNA | |
| SCHEMBL2579697 | 0.77 | PRMT5 (0.46) | MEN1KMT2ATSHRALDH1A1LMNA | |
| SCHEMBL2579693 | 0.77 | PRMT5 (0.46) | MEN1KMT2ATSHRALDH1A1LMNA | |
| SCHEMBL30745373 | 0.77 | KMT2A (0.49) | MEN1KMT2AALDH1A1LMNAUCHL1 | |
| SCHEMBL20949 | 0.77 | PDE8B (0.42) | MEN1KMT2ATSHRALDH1A1LMNA | |
| SCHEMBL20948 | 0.77 | PDE8B (0.42) | MEN1KMT2ATSHRALDH1A1LMNA | |
| SCHEMBL30498622 | 0.76 | UCHL1 (0.48) | MEN1KMT2ATSHRALDH1A1LMNA | |
| SCHEMBL698422 | 0.75 | NR1H2 (0.54) | MEN1KMT2AOPRD1DAGLAKDM1A | |
| SCHEMBL698218 | 0.75 | NR1H2 (0.54) | MEN1KMT2AOPRD1DAGLAKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020247445-A1 | IMIDAZOLO DERIVATIVES, COMPOSITIONS AND METHODS AS OREXIN ANTAGONISTS | HAGER BIOSCIENCES, LLC (US) | 2020-12-10 | — | — | WO | disclosed |
| WO-2020247447-A1 | PYRAZOLE AND IMIDAZOLE DERIVATIVES, COMPOSITIONS AND METHODS AS OREXIN ANTAGONISTS | HAGER BIOSCIENCES, LLC (US) | 2020-12-10 | — | — | WO | disclosed |