Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21901271 | 0.84 | PGK1 (0.34) | PTPN11 | |
| SCHEMBL21900949 | 0.75 | HDAC1 (0.34) | — | |
| SCHEMBL21901148 | 0.69 | — | — | |
| SCHEMBL23883755 | 0.68 | GRM5 (0.38) | — | |
| SCHEMBL20438012 | 0.65 | OPRL1 (0.32) | — | |
| SCHEMBL21856683 | 0.65 | AXL (0.40) | — | |
| SCHEMBL23887277 | 0.61 | HAO1 (0.32) | — | |
| SCHEMBL23707392 | 0.60 | PTPN11 (0.33) | PTPN11 | |
| SCHEMBL25544262 | 0.60 | ALDH1A1 (0.35) | — | |
| SCHEMBL24233251 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022026372-A2 | PROCESSES FOR PREPARING MODULATORS OF ALPHA-1 ANTITRYPSIN | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-02-03 | — | — | WO | disclosed |
| WO-2020247160-A1 | CONDENSED TRYCICLIC PYRROLES AS ALPHA-1 ANTITRYPSIN MODULATORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-12-10 | — | — | WO | disclosed |