Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.60 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.60 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 10/20 | 0.43 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.40 |
| ▸ | MGMT | P16455 | 6/20 | 0.40 |
| ▸ | PNP | P00491 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 9/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 9/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 9/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2,6-Diaminopurine SCHEMBL9220451 | 0.81 | PDPK1 (0.64) | PDPK1GDADPP4CDK2MAP3K5 | |
| 2,6-Diaminopurine SCHEMBL22775219 | 0.79 | CRBN (0.45) | PDPK1GDACRBNADORA2A | |
| 2,6-Diaminopurine SCHEMBL24053 | 0.78 | PDPK1 (1.00) | PDPK1GDADPP4CDK2MAP3K5 | |
| SCHEMBL17200149 | 0.78 | CRBN (0.41) | DPP4CRBNPNPHRH4ADORA2A | |
| 2,6-Diaminopurine SCHEMBL8757979 | 0.76 | PDPK1 (0.96) | PDPK1GDADPP4CDK2MAP3K5 | |
| 2,6-Diaminopurine SCHEMBL27891733 | 0.76 | PDPK1 (0.96) | PDPK1GDADPP4CDK2MAP3K5 | |
| 2,6-Diaminopurine SCHEMBL28206545 | 0.76 | PDPK1 (0.96) | PDPK1GDADPP4CDK2MAP3K5 | |
| 2,6-Diaminopurine SCHEMBL29143272 | 0.75 | PDPK1 (0.92) | PDPK1GDADPP4CDK2MAP3K5 | |
| 2,6-Diaminopurine SCHEMBL160630 | 0.73 | PDPK1 (0.52) | PDPK1GDADPP4CDK2MAP3K5 | |
| 2,6-Diaminopurine SCHEMBL4535059 | 0.72 | PDPK1 (0.79) | PDPK1GDADPP4CDK2MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983393-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | Janssen Pharmaceutica NV (BE) | 2022-04-20 | — | — | EP | disclosed |
| WO-2020249663-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-17 | — | — | WO | disclosed |