Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 8/20 | 0.41 |
| ▸ | P2RX2 | Q9UBL9 | 8/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.35 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.35 |
| ▸ | CTRC | Q99895 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2277566 | 0.90 | DHODH (0.40) | P2RX3P2RX2DHODHP2RY14CTRC | |
| SCHEMBL4173794 | 0.88 | CTRC (0.43) | P2RX3P2RX2DHODHP2RY14CTRC | |
| SCHEMBL2277571 | 0.84 | P2RX3 (0.58) | P2RX3P2RX2 | |
| SCHEMBL3655312 | 0.78 | CTRC (0.40) | P2RX3P2RX2DHODHP2RY14CTRC | |
| SCHEMBL4172507 | 0.76 | DHODH (0.39) | P2RX3P2RX2DHODHP2RY14CTRC | |
| SCHEMBL2276652 | 0.75 | P2RX3 (0.62) | P2RX3P2RX2 | |
| SCHEMBL4327351 | 0.71 | P2RX3 (0.52) | P2RX3P2RX2DHODHP2RY14PPARG | |
| SCHEMBL2275247 | 0.71 | P2RX3 (0.53) | P2RX3P2RX2 | |
| SCHEMBL2278513 | 0.71 | DHODH (0.42) | P2RX3P2RX2DHODHP2RY14CTRC | |
| SCHEMBL10244443 | 0.71 | P2RX3 (0.57) | P2RX3P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989637-B2 | Triazole-substituted arylamides as P2X3 and P2X2/3 antagonists | ROCHE PALO ALTO LLC (US) | 2011-08-02 | — | — | US | claimed |