Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.53 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.49 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.49 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.47 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.47 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.47 |
| ▸ | WNT3A | P56704 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22777877 | 0.86 | RECQL (0.51) | TRPV1KCNQ3KCNQ2DGAT1WNT3A | |
| SCHEMBL22777899 | 0.80 | KDM4E (0.60) | TRPV1KCNQ3KCNQ2RAB9ANPC1 | |
| SCHEMBL22777836 | 0.80 | KDM4E (0.64) | TRPV1KCNQ3KCNQ2DGAT1NPSR1 | |
| SCHEMBL22777838 | 0.80 | KDM4E (0.64) | TRPV1KCNQ3KCNQ2DGAT1NPSR1 | |
| SCHEMBL4969527 | 0.79 | KCNQ3 (0.60) | TRPV1KCNQ3KCNQ2DGAT1RAB9A | |
| SCHEMBL1593432 | 0.77 | KMT2A (0.64) | TRPV1KCNQ3KCNQ2DGAT1RAB9A | |
| SCHEMBL896355 | 0.77 | GAA (0.52) | TRPV1KCNQ3KCNQ2DGAT1RAB9A | |
| SCHEMBL29739388 | 0.77 | GAA (0.52) | TRPV1KCNQ3KCNQ2DGAT1RAB9A | |
| SCHEMBL24645772 | 0.76 | MAPT (0.67) | TRPV1KCNQ3KCNQ2RAB9ASMN1; SMN2 | |
| SCHEMBL27961413 | 0.76 | KCNQ3 (0.56) | TRPV1KCNQ3KCNQ2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220356176-A1 | Kv11.1-3.1 INHIBITING METHODS AND COMPOSITIONS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-11-10 | — | — | US | disclosed |
| WO-2020252130-A1 | KV11.1-3.1 INHIBITING METHODS AND COMPOSITIONS | LIEBER INSTITUTE, INC. (US) | 2020-12-17 | — | — | WO | disclosed |
| WO-2020252130-A1 | KV11.1-3.1 INHIBITING METHODS AND COMPOSITIONS | LIEBER INSTITUTE, INC. (US) | 2020-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220356176-A1 | Kv11.1-3.1 INHIBITING METHODS AND COMPOSITIONS | KCNAB1, KCNMA1, KCNA1 | TRPV1 264/4885KCNQ3 22/4885KCNQ2 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.