Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.57 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.57 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.55 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7490372 | 0.86 | MAPT (0.59) | MAPTKDM4ECYP1A2CYP2C19CYP3A4 | |
| SCHEMBL50482 | 0.85 | MAPT (0.69) | MAPTKDM4ECYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL4969527 | 0.84 | KCNQ3 (0.60) | MAPTKDM4ECYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL4924716 | 0.84 | KCNQ3 (0.57) | MAPTKDM4ECYP1A2CYP2C19KCNQ3 | |
| SCHEMBL27961413 | 0.81 | KCNQ3 (0.56) | MAPTKDM4ECYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL22664052 | 0.81 | KCNQ3 (0.54) | MAPTKDM4ECYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL1984304 | 0.81 | TRPV1 (0.57) | MAPTKDM4ECYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL22777899 | 0.80 | KDM4E (0.60) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4920815 | 0.80 | MAPT (0.69) | MAPTKDM4EKCNQ3KCNQ2SMN1; SMN2 | |
| SCHEMBL13006763 | 0.79 | MAPT (0.49) | MAPTKDM4EALDH1A1GAAKCNQ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220356176-A1 | Kv11.1-3.1 INHIBITING METHODS AND COMPOSITIONS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-11-10 | — | — | US | disclosed |
| US-20220356176-A1 | Kv11.1-3.1 INHIBITING METHODS AND COMPOSITIONS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220356176-A1 | Kv11.1-3.1 INHIBITING METHODS AND COMPOSITIONS | KCNAB1, KCNMA1, KCNA1 | MAPT 2623/4885KDM4E 2187/4885CYP1A2 2283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.