Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21361040 | 0.83 | CHRNB2 (0.39) | CHRNB2CHRNA4CHRNA5CHRNA7KMT2A | |
| SCHEMBL27312693 | 0.73 | TSHR (0.42) | CHRNB2CHRNA4CHRNA5CHRNA7KMT2A | |
| SCHEMBL10389764 | 0.69 | KMT2A (0.42) | CHRNB2CHRNA4CHRNA5CHRNA7KMT2A | |
| SCHEMBL21361041 | 0.68 | GAA (0.37) | CHRNB2CHRNA4 | |
| SCHEMBL27045573 | 0.68 | F2 (0.47) | CHRNB2CHRNA4CHRNA5CHRNA7KMT2A | |
| SCHEMBL1266020 | 0.68 | F2 (0.47) | CHRNB2CHRNA4CHRNA5CHRNA7KMT2A | |
| SCHEMBL26114506 | 0.65 | TDP1 (0.59) | KMT2ALMNAALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL9772117 | 0.65 | SMO (0.36) | KMT2ALMNAALDH1A1MAPTPOLB | |
| SCHEMBL2510973 | 0.64 | KMT2A (0.50) | CHRNB2CHRNA4CHRNA5CHRNA7KMT2A | |
| SCHEMBL25699197 | 0.64 | F2 (0.42) | CHRNB2CHRNA4CHRNA5CHRNA7KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3129372-B1 | AZAQUINAZOLINE INHIBITORS OF ATYPICAL PROTEIN KINASE C | CANCER RESEARCH TECH LTD (GB) | 2020-12-16 | — | — | EP | disclosed |