Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.31 |
| ▸ | GLRB | P48167 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20028325 | 0.81 | SMO (0.36) | SMOHPGDSLTA4HFAAHKMT2A | |
| SCHEMBL20028324 | 0.80 | SMO (0.37) | SMOHPGDSLTA4HFAAHKMT2A | |
| SCHEMBL27312693 | 0.73 | TSHR (0.42) | POLBMAPTALDH1A1KMT2ACASP3 | |
| SCHEMBL20028531 | 0.71 | LTA4H (0.34) | SMOLTA4HKMT2A | |
| SCHEMBL9772056 | 0.70 | CHRM1 (0.31) | LTA4HCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9702274 | 0.68 | SMN1; SMN2 (0.45) | MAPTHDAC4CHRM2CHRM4CHRM5 | |
| SCHEMBL21361040 | 0.68 | CHRNB2 (0.39) | POLBALDH1A1KMT2AF2LMNA | |
| SCHEMBL27045573 | 0.68 | F2 (0.47) | POLBMAPTALDH1A1KMT2ACASP3 | |
| SCHEMBL1266020 | 0.68 | F2 (0.47) | POLBMAPTALDH1A1KMT2ACASP3 | |
| SCHEMBL26429014 | 0.67 | LMNA (0.42) | MAPTKMT2AF2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5053416-A | Alzheimer's disease; central cholinomimetic activity | ROUSSEL UCLAF (FR) | 1991-10-01 | — | — | US | disclosed |
| EP-0376848-A1 | Thiazolyl or oxazolyl substituted 1,2,5,6-tetrahydropyridine derivatives, process and intermediates for their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1990-07-04 | — | — | EP | disclosed |