Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21361040 | 0.79 | CHRNB2 (0.39) | TSHRLMNAF2KMT2AMEN1 | |
| SCHEMBL27045573 | 0.78 | F2 (0.47) | TSHRLMNAF2KMT2AMEN1 | |
| SCHEMBL1266020 | 0.78 | F2 (0.47) | TSHRLMNAF2KMT2AMEN1 | |
| SCHEMBL10389764 | 0.77 | KMT2A (0.42) | TSHRLMNAF2KMT2AMEN1 | |
| SCHEMBL2510973 | 0.74 | KMT2A (0.50) | TSHRLMNAF2KMT2AMEN1 | |
| SCHEMBL25699197 | 0.74 | F2 (0.42) | TSHRLMNAF2KMT2AMEN1 | |
| SCHEMBL1249246 | 0.73 | HPGD (0.53) | TSHRLMNAF2KMT2AMEN1 | |
| SCHEMBL28495717 | 0.73 | HPGD (0.53) | TSHRLMNAF2KMT2AMEN1 | |
| SCHEMBL9772117 | 0.73 | SMO (0.36) | LMNAF2KMT2AALDH1A1MAPT | |
| SCHEMBL22780923 | 0.73 | CHRNB2 (0.34) | TSHRLMNAKMT2AMEN1CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024077244-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISORDERS | HOTSPOT THERAPEUTICS, INC. (US) | 2024-04-11 | — | — | WO | disclosed |