Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 2/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29523064 | 1.00 | AXL (0.43) | AXLIDO1GAAMAPTHTT | |
| SCHEMBL29987187 | 0.81 | AXL (0.41) | AXLIDO1GAAMAPTHTT | |
| SCHEMBL22776087 | 0.81 | AXL (0.41) | AXLIDO1GAAMAPTHTT | |
| SCHEMBL29523066 | 0.79 | AXL (0.39) | AXLIDO1GAAMAPTHTT | |
| SCHEMBL22787654 | 0.79 | AXL (0.39) | AXLIDO1GAAMAPTHTT | |
| SCHEMBL22776072 | 0.78 | AXL (0.38) | AXLIDO1GAAMAPTHTT | |
| SCHEMBL31552048 | 0.78 | MAOA (0.44) | AXLIDO1GAAMAPTHTT | |
| SCHEMBL15055153 | 0.77 | TDO2 (0.38) | IDO1GAAACHECHUKIMPDH2 | |
| SCHEMBL22787692 | 0.76 | AXL (0.55) | AXLIDO1GAAMAPTHTT | |
| SCHEMBL29751394 | 0.76 | AXL (0.55) | AXLIDO1GAAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12391695-B2 | PRMT5 inhibitors | LUPIN LIMITED (IN) | 2025-08-19 | — | — | US | disclosed |
| CN-114026094-B | PRMT5 inhibitors | 印度鲁宾有限公司 | 2024-06-25 | — | — | CN | disclosed |
| EP-3980417-B1 | PRMT5 INHIBITORS | LUPIN LTD (IN) | 2023-09-27 | — | — | EP | disclosed |
| EP-3980417-B1 | PRMT5 INHIBITORS | LUPIN LTD (IN) | 2023-09-27 | — | — | EP | disclosed |
| US-20220315589-A1 | PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2022-10-06 | — | — | US | disclosed |
| US-20220315589-A1 | PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2022-10-06 | — | — | US | disclosed |
| EP-3980417-A1 | PRMT5 INHIBITORS | Lupin Limited (IN) | 2022-04-13 | — | — | EP | disclosed |
| CN-114026094-A | PRMT5 inhibitor | 印度鲁宾有限公司 | 2022-02-08 | — | — | CN | disclosed |
| WO-2020250123-A1 | PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2020-12-17 | — | — | WO | disclosed |
| WO-2020250123-A1 | PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2020-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220315589-A1 | PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT3 | AXL 2715/4885IDO1 1855/4885GAA 885/4885 |
| US-12391695-B2 | PRMT5 inhibitors | PRMT5, PRMT1, PRMT3 | AXL 2715/4885IDO1 1855/4885GAA 885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.