Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 6/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25110212 | 0.88 | KDM4E (0.42) | KDM4EALDH1A1MAPTPKMTDP1 | |
| SCHEMBL25109776 | 0.86 | HRH3 (0.46) | KDM4EALDH1A1MAPTPKMTDP1 | |
| SCHEMBL24513990 | 0.85 | KDM4E (0.41) | KDM4EALDH1A1MAPTPKMTDP1 | |
| SCHEMBL22793930 | 0.85 | KDM4E (0.43) | KDM4EALDH1A1MAPTPKMTDP1 | |
| SCHEMBL22793929 | 0.84 | KDM4E (0.42) | KDM4EALDH1A1MAPTPKMTDP1 | |
| SCHEMBL22793925 | 0.83 | KDM4E (0.39) | KDM4EALDH1A1MAPTPKMTDP1 | |
| SCHEMBL24513989 | 0.83 | KDM4E (0.41) | KDM4EALDH1A1MAPTPKMTDP1 | |
| SCHEMBL25110817 | 0.81 | KDM4E (0.42) | KDM4EALDH1A1MAPTTDP1THRB | |
| SCHEMBL25468397 | 0.79 | KDM4E (0.47) | KDM4EALDH1A1MAPTPKMTDP1 | |
| SCHEMBL25111268 | 0.79 | HRH4 (0.43) | KDM4ETDP1THRBHRH3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020251972-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |