Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 6/20 | 0.34 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25110212 | 0.94 | KDM4E (0.42) | KDM4EALDH1A1MAPTPKMTHRB | |
| SCHEMBL24513989 | 0.91 | KDM4E (0.41) | KDM4EALDH1A1MAPTPKMTHRB | |
| SCHEMBL25109776 | 0.90 | HRH3 (0.46) | KDM4EALDH1A1MAPTPKMTHRB | |
| SCHEMBL24514674 | 0.90 | NCF1 (0.45) | KDM4ETHRBTDP1CXCR4NCF1 | |
| SCHEMBL22794070 | 0.89 | KDM4E (0.37) | KDM4EALDH1A1MAPTTHRBTDP1 | |
| SCHEMBL22790759 | 0.85 | KDM4E (0.42) | KDM4EALDH1A1MAPTPKMTHRB | |
| SCHEMBL22793930 | 0.84 | KDM4E (0.43) | KDM4EALDH1A1MAPTPKMTHRB | |
| SCHEMBL22793929 | 0.83 | KDM4E (0.42) | KDM4EALDH1A1MAPTPKMTHRB | |
| SCHEMBL25111268 | 0.80 | HRH4 (0.43) | KDM4ETHRBTDP1HRH3SMN1; SMN2 | |
| SCHEMBL25108854 | 0.80 | KDM4E (0.39) | KDM4EALDH1A1MAPTPKMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022125804-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |