Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SNCA | P37840 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22793929 | 0.99 | KDM4E (0.42) | KDM4EALDH1A1MAPTPKMHRH3 | |
| SCHEMBL25109776 | 0.92 | HRH3 (0.46) | KDM4EALDH1A1MAPTPKMHRH3 | |
| SCHEMBL25111056 | 0.91 | KDM4E (0.37) | KDM4EALDH1A1MAPTHRH3TDP1 | |
| SCHEMBL25110291 | 0.89 | KDM4E (0.37) | KDM4EALDH1A1MAPTHRH3TDP1 | |
| SCHEMBL24513989 | 0.88 | KDM4E (0.41) | KDM4EALDH1A1MAPTPKMHRH3 | |
| SCHEMBL25110817 | 0.86 | KDM4E (0.42) | KDM4EALDH1A1MAPTHRH3TDP1 | |
| SCHEMBL25108926 | 0.85 | NCF1 (0.48) | KDM4EMAPTHRH3TDP1THRB | |
| SCHEMBL25110212 | 0.85 | KDM4E (0.42) | KDM4EALDH1A1MAPTPKMHRH3 | |
| SCHEMBL22790759 | 0.85 | KDM4E (0.42) | KDM4EALDH1A1MAPTPKMHRH3 | |
| SCHEMBL24513990 | 0.84 | KDM4E (0.41) | KDM4EALDH1A1MAPTPKMHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022125804-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |
| WO-2020251971-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |