Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22790783 | 0.96 | ALDH1A1 (0.58) | RAB9ANPC1ALDH1A1TP53HPGD | |
| SCHEMBL22793928 | 0.94 | ALDH1A1 (0.57) | RAB9ANPC1ALDH1A1TP53HPGD | |
| SCHEMBL24514229 | 0.90 | RAB9A (0.58) | RAB9ANPC1ALDH1A1TP53HPGD | |
| SCHEMBL22802252 | 0.88 | ALDH1A1 (0.66) | RAB9ANPC1ALDH1A1TP53HPGD | |
| SCHEMBL22794081 | 0.87 | RAB9A (0.56) | RAB9ANPC1ALDH1A1TP53HPGD | |
| SCHEMBL22802254 | 0.86 | ALDH1A1 (0.64) | RAB9ANPC1ALDH1A1TP53HPGD | |
| SCHEMBL22790774 | 0.86 | ALDH1A1 (0.68) | RAB9ANPC1ALDH1A1TP53HPGD | |
| SCHEMBL22795022 | 0.85 | RAB9A (0.53) | RAB9ANPC1ALDH1A1TP53HPGD | |
| SCHEMBL25110173 | 0.84 | ALDH1A1 (0.58) | RAB9ANPC1ALDH1A1TP53HPGD | |
| SCHEMBL22790778 | 0.83 | RAB9A (0.57) | RAB9ANPC1ALDH1A1TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022125804-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |
| WO-2020251972-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |
| WO-2020251971-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |