Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.40 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22791290 | 1.00 | PTGDR2 (0.41) | PTGDR2PTGER4SLC6A5DRD4SIGMAR1 | |
| SCHEMBL22791289 | 1.00 | PTGDR2 (0.41) | PTGDR2PTGER4SLC6A5DRD4SIGMAR1 | |
| SCHEMBL22791202 | 0.92 | ACSL1 (0.43) | PTGDR2PTGER4DRD4SIGMAR1 | |
| SCHEMBL22791200 | 0.91 | PTGER4 (0.39) | PTGDR2PTGER4SLC6A5DRD4SIGMAR1 | |
| SCHEMBL29614446 | 0.89 | PTGER4 (0.53) | PTGDR2PTGER4SLC6A5DRD4SIGMAR1 | |
| SCHEMBL22791369 | 0.89 | PTGER4 (0.53) | PTGDR2PTGER4SLC6A5DRD4SIGMAR1 | |
| SCHEMBL22776660 | 0.89 | PTGER4 (0.53) | PTGDR2PTGER4SLC6A5DRD4SIGMAR1 | |
| SCHEMBL22791199 | 0.87 | HTR4 (0.44) | DRD4 | |
| SCHEMBL22791359 | 0.87 | EPHX2 (0.37) | PTGDR2SLC6A5DRD4SIGMAR1CCR2 | |
| SCHEMBL22776540 | 0.81 | PTGER4 (0.42) | PTGDR2PTGER4RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020251957-A1 | PROSTAGLANDIN E2 RECEPTOR 4 ANTAGONISTS AND USES THEREOF | TEON THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |