Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.31 |
| ▸ | BCR | P11274 | 2/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 2/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.31 |
| ▸ | TEK | Q02763 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22791540 | 0.87 | GSK3B (0.36) | GSK3BCRHR1HIF1AEPAS1MAPK10 | |
| SCHEMBL22776728 | 0.84 | HIF1A (0.35) | GSK3BCRHR1HIF1AEPAS1MAPK10 | |
| SCHEMBL29527365 | 0.84 | HIF1A (0.35) | GSK3BCRHR1HIF1AEPAS1MAPK10 | |
| SCHEMBL22791469 | 0.81 | GSK3B (0.38) | GSK3BCRHR1HIF1AEPAS1MAPK10 | |
| SCHEMBL22791527 | 0.81 | GSK3B (0.38) | GSK3BCRHR1HIF1AEPAS1MAPK10 | |
| SCHEMBL22791354 | 0.79 | YTHDC1 (0.46) | GSK3BCRHR1HIF1AEPAS1MAPK10 | |
| SCHEMBL22776597 | 0.78 | GSK3B (0.38) | GSK3BCRHR1HIF1AEPAS1MAPK10 | |
| SCHEMBL29614550 | 0.78 | GSK3B (0.38) | GSK3BCRHR1HIF1AEPAS1MAPK10 | |
| SCHEMBL22791342 | 0.78 | PDE4A (0.35) | — | |
| SCHEMBL22791543 | 0.78 | GSK3B (0.34) | GSK3BCRHR1HIF1AEPAS1MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020251957-A1 | PROSTAGLANDIN E2 RECEPTOR 4 ANTAGONISTS AND USES THEREOF | TEON THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |