Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.34 |
| ▸ | IL1B | P01584 | 6/20 | 0.34 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | PTGFR | P43088 | 1/20 | 0.33 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22791412 | 0.87 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DP2RX7 | |
| SCHEMBL22777090 | 0.85 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DP2RX7 | |
| SCHEMBL22791408 | 0.81 | P2RX7 (0.37) | P2RX7IL1BADAMTS4TBXA2RPTGER1 | |
| SCHEMBL22791491 | 0.81 | P2RX7 (0.37) | PDE4APDE4BPDE4CPDE4DP2RX7 | |
| SCHEMBL22776643 | 0.79 | P2RX7 (0.38) | PDE4APDE4BPDE4CPDE4DP2RX7 | |
| SCHEMBL22791528 | 0.78 | GSK3B (0.36) | — | |
| SCHEMBL22776459 | 0.78 | P2RX7 (0.37) | P2RX7IL1BTBXA2RPTGER1PTGER4 | |
| SCHEMBL22776611 | 0.78 | SRD5A2 (0.41) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL29614440 | 0.76 | CRHR1 (0.44) | PDE4APDE4BPDE4CPDE4DDRD4 | |
| SCHEMBL29614505 | 0.75 | PTGER4 (0.49) | PDE4APDE4BPDE4CPDE4DP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020251957-A1 | PROSTAGLANDIN E2 RECEPTOR 4 ANTAGONISTS AND USES THEREOF | TEON THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |