Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22791511 | 0.81 | CYP3A4 (0.39) | GAASMN1; SMN2LMNATSHRKDM4E | |
| SCHEMBL24292050 | 0.79 | STAT3 (0.36) | GAASMN1; SMN2LMNATSHRMEN1 | |
| SCHEMBL20931145 | 0.79 | KDM4E (0.36) | GAALMNATSHRMEN1KMT2A | |
| SCHEMBL3789681 | 0.77 | SMN1; SMN2 (0.44) | GAASMN1; SMN2LMNATSHRMEN1 | |
| SCHEMBL3398998 | 0.75 | MEN1 (0.50) | GAASMN1; SMN2LMNATSHRMEN1 | |
| SCHEMBL1645546 | 0.73 | TSHR (0.60) | GAALMNATSHRPOLBKDM4E | |
| SCHEMBL19827908 | 0.73 | IDO1 (0.40) | SMN1; SMN2LMNATSHRMEN1KMT2A | |
| SCHEMBL12895731 | 0.73 | ALDH1A1 (0.40) | GAASMN1; SMN2LMNATSHRMEN1 | |
| Hydrochloric Acid SCHEMBL6518247 | 0.73 | MEN1 (0.48) | GAASMN1; SMN2LMNATSHRMEN1 | |
| SCHEMBL16268635 | 0.72 | MEN1 (0.39) | GAASMN1; SMN2LMNATSHREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252205-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC (US) | 2020-12-17 | — | — | WO | disclosed |