Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.33 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22791569 | 0.81 | GAA (0.35) | CYP3A4TSHRRECQLMAPTGAA | |
| SCHEMBL20931145 | 0.81 | KDM4E (0.36) | CYP3A4TSHRRECQLMAPTHTT | |
| SCHEMBL24292050 | 0.81 | STAT3 (0.36) | CYP3A4TSHRRECQLMAPTHTT | |
| SCHEMBL22791425 | 0.78 | GAA (0.37) | CYP3A4CYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL19827908 | 0.76 | IDO1 (0.40) | CYP3A4TSHRRECQLCYP1A2CYP2C19 | |
| SCHEMBL28843159 | 0.76 | TSHR (0.41) | CYP3A4TSHRRECQLCYP1A2CYP2C9 | |
| SCHEMBL2499765 | 0.75 | CYP3A4 (0.64) | CYP3A4TSHRRECQLCYP1A2CYP2C9 | |
| SCHEMBL19337478 | 0.73 | TAAR1 (0.37) | CYP3A4TSHRCYP1A2MAPTALDH1A1 | |
| SCHEMBL8285135 | 0.72 | TSHR (0.41) | CYP3A4TSHRRECQLCYP1A2CYP2C9 | |
| SCHEMBL12327878 | 0.72 | SMN1; SMN2 (0.44) | CYP3A4TSHRRECQLCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252205-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC (US) | 2020-12-17 | — | — | WO | disclosed |