Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.54 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23015729 | 0.84 | TDP1 (0.66) | SMN1; SMN2TSHRTDP1LMNAHIF1A | |
| SCHEMBL23015731 | 0.81 | RAB9A (0.62) | SMN1; SMN2TDP1LMNAHIF1AROCK2 | |
| SCHEMBL22792276 | 0.80 | SMN1; SMN2 (0.76) | SMN1; SMN2TSHRTDP1LMNAHIF1A | |
| SCHEMBL14339876 | 0.80 | SMN1; SMN2 (0.64) | SMN1; SMN2TSHRLMNAHIF1AROCK2 | |
| SCHEMBL11195433 | 0.78 | KMT2A (0.80) | SMN1; SMN2TSHRLMNAHIF1AROCK2 | |
| SCHEMBL22792295 | 0.77 | RAB9A (0.55) | SMN1; SMN2RAB9AMAPTPOLBNPC1 | |
| SCHEMBL4653584 | 0.77 | SMN1; SMN2 (1.00) | SMN1; SMN2TSHRTDP1LMNAHIF1A | |
| SCHEMBL14880158 | 0.75 | RAB9A (0.70) | SMN1; SMN2TSHRTDP1LMNAHIF1A | |
| SCHEMBL23015732 | 0.75 | TDP1 (0.78) | SMN1; SMN2TSHRTDP1LMNAHIF1A | |
| SCHEMBL1571386 | 0.75 | LMNA (1.00) | TDP1LMNAHIF1AROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252229-A2 | INHIBITORS OF SARM1 | DISARM THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |