SCHEMBL1571386

SCHEMBL1571386

O=C(Nc1cccnc1)c1cccnc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 1.00
HIF1A Q16665 1/20 1.00
NAMPT P43490 6/20 0.83
ROCK2 O75116 1/20 0.77
ROCK1 Q13464 1/20 0.77
KCNK3 O14649 1/20 0.73
CYP11B1 P15538 3/20 0.71
CYP11B2 P19099 3/20 0.71
CLK2 P49760 1/20 0.69
CLK3 P49761 1/20 0.69
DYRK1A Q13627 1/20 0.69
NPC1 O15118 2/20 0.69
RAB9A P51151 2/20 0.69
GAA P10253 1/20 0.69
TDP1 Q9NUW8 1/20 0.69
PIM1 P11309 1/20 0.67
PIM3 Q86V86 1/20 0.67
PIM2 Q9P1W9 1/20 0.67
MEN1 O00255 1/20 0.66
KMT2A Q03164 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nicotinanilide SCHEMBL29067673 0.91 LMNA (0.83) LMNAHIF1ANAMPTROCK2ROCK1
Nicotinanilide SCHEMBL352439 0.91 LMNA (0.83) LMNAHIF1ANAMPTROCK2ROCK1
SCHEMBL167081 0.91 NAMPT (1.00) LMNAHIF1ANAMPTKCNK3CYP11B1
Nicotinanilide SCHEMBL8155304 0.89 LMNA (0.81) LMNAHIF1ANAMPTROCK2ROCK1
SCHEMBL30533390 0.89 LMNA (0.81) LMNAHIF1ANAMPTKCNK3CYP11B1
Hydrochloric Acid SCHEMBL27890956 0.89 NAMPT (0.97) LMNAHIF1ANAMPTKCNK3CYP11B1
SCHEMBL19520187 0.89 LMNA (0.81) LMNAHIF1ANAMPTROCK2ROCK1
SCHEMBL14880208 0.87 ROCK2 (1.00) LMNAHIF1ANAMPTROCK2ROCK1
SCHEMBL28007807 0.87 NAMPT (0.81) LMNAHIF1ANAMPTROCK2ROCK1
SCHEMBL12707716 0.85 LMNA (0.73) LMNAHIF1ANAMPTCYP11B1CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260028685-A1 Saliva Stabilization Solution For Use In Nucleic Acid Amplification Reactions And Methods Of Use For The Detection Of Pathogen Nucleic Acids UNIV COLORADO REGENTS (US) 2026-01-29 US claimed
WO-2021236696-A1 SALIVA STABILIZATION SOLUTION FOR USE IN NUCLEIC ACID AMPLIFICATION REACTIONS AND METHODS OF USE FOR THE DETECTION OF PATHOGEN NUCLEIC ACIDS THE REGENTS OF THE UNIVERSITY OF COLORADO A BODY CORPORATE (US) 2021-11-25 WO claimed
US-12590955-B2 Methods and systems for processing particles ZEON CORPORATION (JP) 2026-03-31 US disclosed
US-20260071299-A1 APPARATUS AND METHODS FOR RARE EARTH ELEMENT RECOVERY AND PURIFICATION BATTELLE MEMORIAL INSTITUTE (US) 2026-03-12 US disclosed
US-20250381163-A1 Chelating Agents for Use in Cancer Therapy PLECO THERAPEUTICS B V (NL) 2025-12-18 US disclosed
US-12436081-B2 Methods and devices for multi-step cell purification and concentration ZEON CORPORTION (JP) 2025-10-07 US disclosed
WO-2025089964-A1 METHODS FOR TESTING ACTIVE COMPOUNDS IN MODELS WITH ELEVATED HEAVY METAL ACCUMULATION PLECO THERAPEUTICS B.V. (NL) 2025-05-01 WO disclosed
EP-4529456-A1 CHELATING AGENTS FOR USE IN CANCER THERAPY Pleco Therapeutics B.V. (NL) 2025-04-02 EP disclosed
US-12258535-B2 Emulsions having oil phase surfactants and water phase additive blends PILOT CHEMICAL CORP. (US) 2025-03-25 US disclosed
CN-119630394-A Chelating agents for cancer treatment 普雷高治疗有限公司 2025-03-14 CN disclosed
US-20240368734-A1 METHODS FOR EXTRACTING RARE EARTH ELEMENTS FROM RARE EARTH ELEMENT SOURCES VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. 2024-11-07 US disclosed
EP-2794569-A1 HETEROCYCLIC UREA COMPOUNDS Biota Europe Ltd (GB) 2014-10-29 EP disclosed
WO-2014151491-A1 METAL COMPLEXING AGENTS AS CORROSION INHIBITORS PRC-DESOTO INTERNATIONAL, INC. (US) 2014-09-25 WO disclosed
WO-2014145152-A2 ON-CHIP MICROFLUIDIC PROCESSING OF PARTICLES GPB SCIENTIFIC, LLC (US) 2014-09-18 WO disclosed
WO-2014145075-A2 METHODS AND DEVICES FOR HIGH THROUGHPOUT PURIFICATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2014-09-18 WO disclosed
US-20140031547-A1 CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES ELECTROPHORETICS LIMITED 2014-01-30 US disclosed
WO-2013091011-A1 HETEROCYCLIC UREA COMPOUNDS BIOTA EUROPE LTD (GB) 2013-06-27 WO disclosed
EP-2307409-A1 PYRROLOPYRIDINES AS KINASE INHIBITORS Array Biopharma, Inc. (US) 2011-04-13 EP disclosed
WO-2009140320-A1 PYRROLOPYRIDINES AS KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2009-11-19 WO disclosed
EP-1389618-A1 PYRAZOLO 1,5-A]PYRIDINES AND MEDICINES CONTAINING THE SAME Eisai Co., Ltd. (JP) 2004-02-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260071299-A1 APPARATUS AND METHODS FOR RARE EARTH ELEMENT RECOVERY AND PURIFICATION ERCC4, ERCC2, XPA LMNA 556/4885HIF1A 825/4885NAMPT 3884/4885
US-20260028685-A1 Saliva Stabilization Solution For Use In Nucleic Acid Amplification Reactions And Methods Of Use For The Detection Of Pathogen Nucleic Acids RNASEH1, ACE2, DDX42 LMNA 3512/4885HIF1A 2730/4885NAMPT 2292/4885
US-20140031547-A1 CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES CSNK1G1, CSNK1A1, CSNK1G3 LMNA 1627/4885HIF1A 1940/4885NAMPT 2344/4885
US-12590955-B2 Methods and systems for processing particles EZR, CD47, CD44 LMNA 571/4885HIF1A 2068/4885NAMPT 3975/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.