Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 6/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 5/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24455226 | 0.82 | TRPA1 (0.54) | TRPA1CHEK1KDM4EMAPK1AXL | |
| SCHEMBL19522374 | 0.82 | TRPA1 (0.53) | TRPA1CHEK1KDM4ETRPM8TRPV1 | |
| SCHEMBL17120530 | 0.77 | TRPA1 (0.50) | TRPA1CHEK1KDM4ETRPM8TRPV1 | |
| SCHEMBL21901141 | 0.76 | CHEK1 (0.63) | TRPA1CHEK1KDM4EMAPK1AXL | |
| SCHEMBL20618760 | 0.76 | TRPA1 (0.50) | TRPA1CHEK1KDM4ETRPM8TRPV1 | |
| SCHEMBL27445825 | 0.76 | TRPA1 (0.52) | TRPA1CHEK1KDM4EMAPK1AXL | |
| SCHEMBL7989217 | 0.75 | TRPA1 (0.48) | TRPA1CHEK1KDM4EMAPK1AXL | |
| SCHEMBL19792713 | 0.73 | TRPA1 (0.53) | TRPA1CHEK1KDM4ETRPM8TRPV1 | |
| SCHEMBL21341663 | 0.73 | AXL (0.61) | TRPA1CHEK1KDM4ETRPM8TRPV1 | |
| SCHEMBL24446592 | 0.73 | TRPA1 (0.47) | TRPA1CHEK1KDM4EMAPK1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200392128-A1 | NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2020-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200392128-A1 | NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS | PTPN5, PTPN1, PTPRJ | TRPA1 4043/4885CHEK1 3411/4885KDM4E 1233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.