Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.32 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.32 |
| ▸ | KDM4A | O75164 | 2/20 | 0.32 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26224162 | 1.00 | MAPK1 (0.37) | MAPK1MEN1FAAHKMT2AEPHX1 | |
| SCHEMBL25479251 | 1.00 | MAPK1 (0.37) | MAPK1MEN1FAAHKMT2AEPHX1 | |
| SCHEMBL24513936 | 0.92 | KDM4E (0.33) | MAPK1MEN1FAAHKMT2AKDM4E | |
| SCHEMBL24313419 | 0.85 | ARG1 (0.33) | MAPK1MEN1FAAHKMT2AEPHX1 | |
| SCHEMBL20046942 | 0.84 | KDM4E (0.36) | MEN1KMT2AKDM4EALDH1A1HRH3 | |
| SCHEMBL25853757 | 0.83 | CASP2 (0.40) | MAPK1MEN1FAAHKMT2AEPHX1 | |
| SCHEMBL23729381 | 0.79 | PAOX (0.52) | MAPK1MEN1FAAHKMT2AEPHX1 | |
| SCHEMBL25453657 | 0.79 | PAOX (0.52) | MAPK1MEN1FAAHKMT2AEPHX1 | |
| SCHEMBL25090250 | 0.79 | PAOX (0.52) | MAPK1MEN1FAAHKMT2AEPHX1 | |
| SCHEMBL25453158 | 0.79 | PAOX (0.52) | MAPK1MEN1FAAHKMT2AEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020251971-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |