Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22795022 | 0.89 | RAB9A (0.53) | SIGMAR1ALDH1A1HTTSMN1; SMN2NPC1 | |
| SCHEMBL22794049 | 0.89 | ALDH1A1 (0.57) | SIGMAR1ALDH1A1HTTSMN1; SMN2GAA | |
| SCHEMBL25481326 | 0.88 | RAB9A (0.52) | SIGMAR1ALDH1A1HTTSMN1; SMN2NPC1 | |
| SCHEMBL22795014 | 0.87 | MEN1 (0.55) | ALDH1A1HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL22794246 | 0.87 | ALDH1A1 (0.54) | SIGMAR1ALDH1A1HTTSMN1; SMN2NPC1 | |
| SCHEMBL25108464 | 0.87 | SIGMAR1 (0.48) | SIGMAR1ALDH1A1PLA2G2ANPC1RAB9A | |
| SCHEMBL25108460 | 0.86 | ALDH1A1 (0.52) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL25109381 | 0.86 | ALDH1A1 (0.53) | ALDH1A1HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL24514285 | 0.86 | ALDH1A1 (0.53) | ALDH1A1HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL24514523 | 0.86 | ALDH1A1 (0.53) | SIGMAR1ALDH1A1HTTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020251971-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |