Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | GMNN | O75496 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | RORC | P51449 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 7/20 | 0.55 |
| ▸ | HTR2C | P28335 | 3/20 | 0.55 |
| ▸ | HTR1D | P28221 | 2/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.55 |
| ▸ | HTR3B | O95264 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22796309 | 0.88 | LMNA (0.52) | LMNAKDM4EADRB2ADRA2AMEN1 | |
| SCHEMBL22796411 | 0.86 | TP53 (0.52) | LMNAKDM4EADRB2ADRA2AMEN1 | |
| SCHEMBL22796306 | 0.78 | HTR3E (0.57) | LMNAKDM4EADRB2ADRA2AMEN1 | |
| SCHEMBL22796307 | 0.77 | TP53 (0.51) | LMNAKDM4EADRB2ADRA2AMEN1 | |
| SCHEMBL22796772 | 0.77 | HTR2C (0.60) | LMNAKDM4EADRB2ADRA2AMEN1 | |
| SCHEMBL22796776 | 0.73 | HTR2C (0.56) | LMNAKDM4EADRB2ADRA2AMEN1 | |
| Maleic Acid SCHEMBL29931110 | 0.73 | KDM4E (1.00) | LMNAKDM4EADRB2ADRA2AMEN1 | |
| Maleic Acid SCHEMBL30011289 | 0.73 | KDM4E (1.00) | LMNAKDM4EADRB2ADRA2AMEN1 | |
| Maleic Acid SCHEMBL7746196 | 0.73 | KDM4E (1.00) | LMNAKDM4EADRB2ADRA2AMEN1 | |
| Fumaric Acid SCHEMBL7746202 | 0.73 | KDM4E (1.00) | LMNAKDM4EADRB2ADRA2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252195-A1 | TELOMERASE REVERSE TRANSCRIPTASE DEGRADERS AND METHODS OF USE THEREOF | THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2020-12-17 | — | — | WO | disclosed |