Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22796411 | 0.90 | TP53 (0.52) | TP53THRBKDM4EMAPTTSHR | |
| SCHEMBL22796309 | 0.87 | LMNA (0.52) | TP53THRBKDM4EMAPTTSHR | |
| SCHEMBL22796308 | 0.77 | LMNA (0.57) | TP53THRBKDM4EMAPTTSHR | |
| SCHEMBL22796306 | 0.72 | HTR3E (0.57) | TP53KDM4EMAPTTSHRLMNA | |
| SCHEMBL3778276 | 0.71 | SHMT2 (0.49) | THRBKDM4EMAPTNPSR1TSHR | |
| SCHEMBL19078360 | 0.69 | ALDH1A1 (0.48) | THRBKDM4EMAPTTSHRALDH1A1 | |
| SCHEMBL22539563 | 0.69 | ALDH1A1 (0.48) | THRBKDM4EMAPTTSHRALDH1A1 | |
| SCHEMBL19078359 | 0.69 | ALDH1A1 (0.48) | THRBKDM4EMAPTTSHRALDH1A1 | |
| SCHEMBL31065690 | 0.69 | ALDH1A1 (0.64) | TP53THRBKDM4EMAPTNPSR1 | |
| SCHEMBL23168873 | 0.68 | SHMT2 (0.42) | TP53THRBKDM4EMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252195-A1 | TELOMERASE REVERSE TRANSCRIPTASE DEGRADERS AND METHODS OF USE THEREOF | THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2020-12-17 | — | — | WO | disclosed |