Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 11/20 | 0.80 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.80 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.72 |
| ▸ | MAPT | P10636 | 6/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.72 |
| ▸ | MEN1 | O00255 | 6/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.72 |
| ▸ | HPGD | P15428 | 4/20 | 0.72 |
| ▸ | HTT | P42858 | 3/20 | 0.72 |
| ▸ | TP53 | P04637 | 1/20 | 0.72 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.69 |
| ▸ | TSHR | P16473 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8001918 | 0.92 | ADORA1 (0.80) | ADORA1ADORA2AADORA2BALDH1A1MAPT | |
| SCHEMBL12376586 | 0.90 | ADORA1 (0.67) | ADORA1ADORA2AADORA2BALDH1A1MAPT | |
| SCHEMBL3368591 | 0.85 | ADORA1 (1.00) | ADORA1ADORA2AADORA2BALDH1A1MEN1 | |
| SCHEMBL1028854 | 0.85 | ALDH1A1 (0.79) | ADORA1ADORA2AADORA2BALDH1A1MAPT | |
| SCHEMBL1029514 | 0.84 | ALDH1A1 (0.78) | ADORA1ADORA2AADORA2BALDH1A1MAPT | |
| SCHEMBL1030844 | 0.84 | ALDH1A1 (1.00) | ADORA1ADORA2AADORA2BALDH1A1MAPT | |
| SCHEMBL1028888 | 0.84 | ALDH1A1 (0.78) | ADORA1ADORA2AADORA2BALDH1A1MAPT | |
| SCHEMBL5040253 | 0.83 | ALDH1A1 (0.85) | ADORA1ADORA2AADORA2BALDH1A1MAPT | |
| SCHEMBL12376547 | 0.83 | ADORA1 (0.67) | ADORA1ADORA2AADORA2BALDH1A1MAPT | |
| SCHEMBL3365679 | 0.82 | ADORA1 (0.82) | ADORA1ADORA2AADORA2BADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426602-B2 | Heteroaryl-substituted dicyanopyridines and their use | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-04-23 | — | — | US | disclosed |
| US-8426602-B2 | Heteroaryl-substituted dicyanopyridines and their use | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-04-23 | — | — | US | disclosed |
| US-20110207698-A1 | HETEROARYL-SUBSTITUTED DICYANOPYRIDINES AND THEIR USE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-08-25 | — | — | US | disclosed |
| US-20110207698-A1 | HETEROARYL-SUBSTITUTED DICYANOPYRIDINES AND THEIR USE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-08-25 | — | — | US | disclosed |
| WO-2009112155-A1 | HETEROARYL-SUBSTITUTED DICYANOPYRIDINES AND USE THEREOF FOR TREATMENT OF CARDIOVASCULAR DISEASES | BAYER SCHERING PHARMA AG (DE) | 2009-09-17 | — | — | WO | disclosed |
| WO-2009112155-A1 | HETEROARYL-SUBSTITUTED DICYANOPYRIDINES AND USE THEREOF FOR TREATMENT OF CARDIOVASCULAR DISEASES | BAYER SCHERING PHARMA AG (DE) | 2009-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207698-A1 | HETEROARYL-SUBSTITUTED DICYANOPYRIDINES AND THEIR USE | QDPR, TNNI3, SDHA | ADORA1 3151/4885ADORA2A 2400/4885ADORA2B 2760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.