Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.39 |
| ▸ | GSTA2 | P09210 | 1/20 | 0.38 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.38 |
| ▸ | GSTM1 | P09488 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 2/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22797422 | 1.00 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3HTR2AHTR2C | |
| SCHEMBL24674004 | 0.90 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3HTR2AHTR2C | |
| SCHEMBL22798838 | 0.86 | ALDH1A1 (0.38) | GSTP1MEN1KMT2AALDH1A1 | |
| SCHEMBL22797481 | 0.86 | ALDH1A1 (0.38) | GSTP1MEN1KMT2AALDH1A1 | |
| SCHEMBL24674006 | 0.86 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3HTR2AHTR2C | |
| SCHEMBL22797429 | 0.85 | GSTA2 (0.40) | SLC6A2SLC6A4SLC6A3HTR2AHTR2C | |
| SCHEMBL18371665 | 0.83 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3HTR2AHTR2C | |
| SCHEMBL22799884 | 0.82 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3HTR2AHTR2C | |
| SCHEMBL20959993 | 0.82 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3HTR2AHTR2C | |
| SCHEMBL16708499 | 0.82 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220275018-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | JANSSEN PHARMACEUTICA NV (BE) | 2022-09-01 | — | — | US | disclosed |
| WO-2020249663-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220275018-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | NME2, SLC28A1, SLC28A2 | SLC6A2 789/4885SLC6A4 778/4885SLC6A3 558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.