Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.32 |
| ▸ | GLB1 | P16278 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22797481 | 1.00 | ALDH1A1 (0.38) | ALDH1A1MEN1KMT2AHPGDPOLB | |
| SCHEMBL22797422 | 0.86 | SLC6A2 (0.39) | ALDH1A1MEN1KMT2AGSTP1 | |
| SCHEMBL22797480 | 0.86 | SLC6A2 (0.39) | ALDH1A1MEN1KMT2AGSTP1 | |
| SCHEMBL22584997 | 0.84 | ALDH1A1 (0.34) | ALDH1A1MEN1KMT2ABCHEIDO1 | |
| SCHEMBL22797485 | 0.82 | ALDH1A1 (0.36) | ALDH1A1BCHEIDO1MAPTCYP2C19 | |
| SCHEMBL18671589 | 0.81 | ALDH1A1 (0.38) | ALDH1A1MEN1KMT2ABCHEIDO1 | |
| SCHEMBL22797519 | 0.81 | OPRM1 (0.36) | ALDH1A1MEN1KMT2ABCHEIDO1 | |
| SCHEMBL22797551 | 0.81 | ALDH1A1 (0.34) | ALDH1A1MEN1KMT2ABCHEIDO1 | |
| SCHEMBL22797550 | 0.81 | ALDH1A1 (0.34) | ALDH1A1MEN1KMT2ABCHEIDO1 | |
| SCHEMBL22797533 | 0.81 | OPRM1 (0.36) | ALDH1A1MEN1KMT2ABCHEIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220275018-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | JANSSEN PHARMACEUTICA NV (BE) | 2022-09-01 | — | — | US | disclosed |
| WO-2020249663-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220275018-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | NME2, SLC28A1, SLC28A2 | ALDH1A1 248/4885MEN1 2703/4885KMT2A 3970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.