Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.51 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.50 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 6/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30091380 | 0.87 | PDCD1 (0.69) | EPHX1PDCD1CD274ALDH1A1KCNA5 | |
| SCHEMBL11074941 | 0.87 | PDCD1 (0.69) | EPHX1PDCD1CD274ALDH1A1KCNA5 | |
| SCHEMBL9285273 | 0.84 | KCNA5 (0.59) | ALDH1A1KMT2ALMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL22272472 | 0.83 | CYP2A6 (0.46) | ALDH1A1KMT2ALMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL23066174 | 0.80 | CD274 (0.46) | EPHX1PDCD1CD274LMNASMN1; SMN2 | |
| SCHEMBL21742825 | 0.79 | PTGS2 (0.54) | EPHX1PDCD1CD274ALDH1A1SMN1; SMN2 | |
| SCHEMBL18378751 | 0.79 | CYP2A6 (0.56) | ALDH1A1LMNASMN1; SMN2CYP2A6PARP10 | |
| SCHEMBL607544 | 0.78 | CD274 (0.71) | EPHX1PDCD1CD274KMT2A | |
| SCHEMBL4248368 | 0.77 | CYP2A6 (0.50) | ALDH1A1LMNASMN1; SMN2CYP2A6PARP10 | |
| SCHEMBL1771368 | 0.76 | TP53 (0.50) | ALDH1A1LMNASMN1; SMN2CYP2A6PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200392170-A1 | COT MODULATORS AND METHODS OF USE THEREOF | GILEAD SCIENCES, INC. | 2020-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200392170-A1 | COT MODULATORS AND METHODS OF USE THEREOF | BRDT, THRB, HCCS | EPHX1 1998/4885PDCD1 3404/4885CD274 2821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.