Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22818556 | 0.90 | EGLN2 (0.32) | EGLN2SMN1; SMN2MAPT | |
| SCHEMBL22800558 | 0.89 | ALDH1A1 (0.34) | SMN1; SMN2ALDH1A1POLBTSHRKMT2A | |
| SCHEMBL4492166 | 0.86 | EGLN2 (0.35) | EGLN2SMN1; SMN2MAPTALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL4488768 | 0.85 | EGLN2 (0.35) | EGLN2SMN1; SMN2MAPTALDH1A1POLB | |
| SCHEMBL22800557 | 0.84 | CRHR1 (0.32) | EGLN2 | |
| SCHEMBL22800539 | 0.84 | CRHR1 (0.32) | EGLN2 | |
| SCHEMBL22800540 | 0.84 | CRHR1 (0.32) | EGLN2 | |
| Hydrochloric Acid SCHEMBL4488767 | 0.84 | EGLN2 (0.34) | EGLN2SMN1; SMN2MAPTALDH1A1POLB | |
| SCHEMBL22800546 | 0.84 | ALDH1A1 (0.35) | ALDH1A1POLBTSHRKMT2A | |
| SCHEMBL25120956 | 0.82 | EGLN2 (0.31) | EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11623927-B2 | Substituted [1,2,4]triazolo[1,5-a]pyrimidines for stabilizing microtubules | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2023-04-11 | — | — | US | disclosed |
| US-11623927-B2 | Substituted [1,2,4]triazolo[1,5-a]pyrimidines for stabilizing microtubules | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2023-04-11 | — | — | US | disclosed |
| US-20200399269-A1 | [1,2,4]TRIAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND USE IN STABILIZING MICROTUBULES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2020-12-24 | — | — | US | disclosed |
| US-20200399269-A1 | [1,2,4]TRIAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND USE IN STABILIZING MICROTUBULES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2020-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11623927-B2 | Substituted [1,2,4]triazolo[1,5-a]pyrimidines for stabilizing microtubules | TUBB1, TUBA1B, TUBA1C | EGLN2 4628/4885SMN1; SMN2 12/4885MAPT 10/4885 |
| US-20200399269-A1 | [1,2,4]TRIAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND USE IN STABILIZING MICROTUBULES | TUBA1C, TUBB1, TUBA8 | EGLN2 4705/4885SMN1; SMN2 7/4885MAPT 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.