Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 3/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | PTPRF | P10586 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1169849 | 0.93 | LOXL2 (0.55) | TSHRCYP2C19CYP1A2LOXL2ALDH1A1 | |
| SCHEMBL11655383 | 0.87 | CA12 (0.50) | TSHRCYP2C19CYP1A2LOXL2ALDH1A1 | |
| SCHEMBL28190734 | 0.83 | BCHE (0.50) | TSHRCYP2C19CYP1A2LOXL2IDO1 | |
| SCHEMBL4768553 | 0.78 | LOXL2 (0.52) | TSHRCYP2C19CYP1A2LOXL2ALDH1A1 | |
| Bicarbonate SCHEMBL9023828 | 0.77 | KMT2A (0.49) | TSHRCYP2C19CYP1A2LOXL2TDP1 | |
| SCHEMBL9528716 | 0.77 | LOXL2 (0.59) | TSHRCYP2C19CYP1A2LOXL2ALDH1A1 | |
| SCHEMBL483755 | 0.77 | LOXL2 (0.59) | TSHRCYP2C19CYP1A2LOXL2ALDH1A1 | |
| Allyl Alcohol SCHEMBL28052693 | 0.77 | TSHR (0.55) | TSHRCYP2C19LOXL2TDP1ALDH1A1 | |
| Hydrogen Peroxide SCHEMBL5496256 | 0.76 | ALDH1A1 (0.58) | TSHRCYP1A2TDP1ALDH1A1MAPT | |
| Bicarbonate SCHEMBL31202990 | 0.76 | MAPT (0.55) | TSHRCYP2C19CYP1A2LOXL2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3986956-A1 | MODIFIED POLYAMINE POLYMERS FOR DELIVERY OF BIOMOLECULES INTO CELLS | Promega Corporation (US) | 2022-04-27 | — | — | EP | disclosed |
| WO-2020263825-A1 | MODIFIED POLYAMINE POLYMERS FOR DELIVERY OF BIOMOLECULES INTO CELLS | PROMEGA CORPORATION (US) | 2020-12-30 | — | — | WO | disclosed |
| US-20200399660-A1 | MODIFIED POLYAMINE POLYMERS FOR DELIVERY OF BIOMOLECULES INTO CELLS | PROMEGA CORPORATION | 2020-12-24 | — | — | US | disclosed |
| CN-105873910-A | Macrocyclic insulin-degrading enzyme (IDE) inhibitors and uses thereof | 哈佛大学的校长及成员们 | 2016-08-17 | — | — | CN | disclosed |