Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 6/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | LPL | P06858 | 5/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 5/20 | 0.43 |
| ▸ | F11 | P03951 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22805607 | 0.90 | HRH3 (0.46) | LTA4HACHEHRH3LPLLIPG | |
| SCHEMBL18579804 | 0.84 | ALDH1A1 (0.49) | LTA4HACHEHRH3LPLLIPG | |
| SCHEMBL21755926 | 0.83 | HRH3 (0.58) | LTA4HACHEHRH3LPLLIPG | |
| SCHEMBL3260869 | 0.83 | LPL (0.49) | LTA4HACHEHRH3LPLLIPG | |
| SCHEMBL24495239 | 0.82 | LPL (0.47) | HRH3LPLLIPGF11 | |
| SCHEMBL24847168 | 0.82 | LPL (0.39) | LPLLIPGF11 | |
| SCHEMBL18580424 | 0.82 | ALDH1A1 (0.49) | LPLLIPGF11 | |
| SCHEMBL18580899 | 0.82 | LPL (0.48) | LTA4HACHEHRH3LPLLIPG | |
| SCHEMBL27194640 | 0.81 | LPL (0.43) | HRH3LPLLIPGF11 | |
| SCHEMBL1428042 | 0.81 | LPL (0.44) | LTA4HHRH3LPLLIPGF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3986896-A1 | EGFR INHIBITORS FOR THE TREATMENT OF CANCER | F. Hoffmann-La Roche AG (CH) | 2022-04-27 | — | — | EP | disclosed |
| CN-113993872-A | EGFR inhibitors for the treatment of cancer | 豪夫迈·罗氏有限公司 | 2022-01-28 | — | — | CN | disclosed |
| WO-2020254572-A1 | EGFR INHIBITORS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2020-12-24 | — | — | WO | disclosed |